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Disease

Atrial septal defect

Late-stage therapeutic development
Also known as ASD, Atrial Septal Defects, atrial septum defect, atrioseptal defect+6 more

ASD, Atrial Septal Defects, atrial septum defect, atrioseptal defect, auricular septal defect, congenital atrial septal defect, interatrial septal defect, interauricular communication, interauricular septal defect, interatrial communication.

6
Clinical trials
12
Associated genes
3
Related proteins
Current focus
Mucin-2 biologyMyosin-6 biologyTherapeutic development

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones (1 completed or reporting results).
Clinical Milestones1View
Recently completed 1
Activity timeline1

Clinical trials

5 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
6
All trials
1
Active
3
Late-stage
4
Completed
Recently completed

The Role of Thiamine on Left Ventricular Structure and Function After Transcatheter Closure Through the Examination of MMP-9 Dan TIMP-1 in Children With Left-to-Right Shunt Congenital Heart Disease

Early Phase 1 · Completed · Universitas Sumatera Utara

Pain Control With Regional Anesthesia Following Pediatric Cardiac Surgery: A Randomized Double-Blinded Pilot Study

Phase 4 · Completed · Duke University

Utilization of Confocal Microscopy During Cardiac Surgery

Phase 1 · Completed · Aditya Kaza

Phase IB Double Blind, Randomized, Placebo Controlled Clinical Trial to Determine the Pharmacokinetics and Safety of a Revised Protocol of Intravenous L-Citrulline (Citrupress®) Versus Placebo in Children Undergoing Cardiopulmonary Bypass

Phase 1/2 · Completed · Asklepion Pharmaceuticals, LLC

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

TBX200.75NKX2-50.73TLL10.65GATA60.58ACTC10.55MYH60.54SEC24B0.34VSIG100.32KIF16B0.29TMTC40.29HSD17B20.29EDIL30.29

Disease biology

3 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Transcription factor GATA-6via GATA60.58Myosin-6via MYH60.54Mucin-2via MUC20.22

Reference

Authoritative identity, definition & identifiers.

Synonyms

ASD, Atrial Septal Defects, atrial septum defect, atrioseptal defect, auricular septal defect, congenital atrial septal defect, interatrial septal defect, interauricular communication, interauricular septal defect, interatrial communication

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.