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Disease
Atrioventricular Block
Late-stage therapeutic developmentEmerging research
1
Publications
10
Clinical trials
12
Associated genes
1
Related proteins
2020
Latest publication
Current focus
Cytidine deaminase biologyTherapeutic developmentGenetics & risk factors
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Research2020-01-27Circulation
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 3 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
- Q1 2027Remote ECG Monitoring as a Diagnostic Tool for Therapeutic Strategies After Transcatheter Aortic Valve Replacement: Rationale and Design of the DRAGON-TAVI Trial.
- Q4 2028Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
- Q4 2029Prospective Multicenter Randomized Controlled Trial Evaluating the Benefit of Left Bundle Branch Area Stimulation Compared With Conventional Pacing in Post-TAVI Atrioventricular Atrioventricular Block
Major developments
Upcoming trial readoutImportant
Results expected Q4 20282026-04-06
Upcoming trial readoutImportant
Results expected Q4 20292026-04-15
Clinical MilestonesViewHide
Results expected
- 2026-04-15Prospective Multicenter Randomized Controlled Trial Evaluating the Benefit of Left Bundle Branch Area Stimulation Compared With Conventional Pacing in Post-TAVI Atrioventricular Atrioventricular BlockResults expected Q4 2029
- 2026-04-13Remote ECG Monitoring as a Diagnostic Tool for Therapeutic Strategies After Transcatheter Aortic Valve Replacement: Rationale and Design of the DRAGON-TAVI Trial.Results expected Q1 2027
- 2026-04-06Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)Results expected Q4 2028
Recently completed
Activity timeline5
- 2026-08-31ClinicalTELE-monitoring for Standard Pacemaker Implantation or Delayed Pacemaker Implantation After Autonomic/Electrophysiologic Evaluation and Cardioneuroablation for managEment of Functional atrioventriculaR Block - Randomized Controlled StudyPrimary completion
- 2026-04-16ClinicalRandomized Assessment of Left Bundle Branch Area Pacing Versus Right Ventricular Pacing in Post-TAVR Patients With Persistent High-Degree Atrioventricular Block or Complete Heart Block Requiring Permanent Pacemaker ImplantationWithdrawn
- 2026-04-15ClinicalProspective Multicenter Randomized Controlled Trial Evaluating the Benefit of Left Bundle Branch Area Stimulation Compared With Conventional Pacing in Post-TAVI Atrioventricular Atrioventricular BlockResults expected Q4 2029
- 2026-04-13ClinicalRemote ECG Monitoring as a Diagnostic Tool for Therapeutic Strategies After Transcatheter Aortic Valve Replacement: Rationale and Design of the DRAGON-TAVI Trial.Results expected Q1 2027
- 2026-04-06ClinicalSurveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)Results expected Q4 2028
Clinical trials
The current development programme across all trial phases.
Clinical programme
10
6
1
3
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Most influential
Major themes1
- Genetic Predisposition to Disease1
Leading journals1
- Circulation1
Leading researchers8
- Abiusi E1
- Ackerman MJ1
- Adler A1
- Amenta S1
- Amin AS1
- Bikker H1
- Care M1
- Feilotter H1
Affiliations (unnormalised)6
- Columbia University Irving Medical Center1
- Department of Clinical Genetics (E.A.N.1
- Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico1
- Geisinger Genomic Medicine Institute1
- Heart Center1
- National Heart and Lung Institute and Medical Research Council London Institute of Medical Sciences1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.