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Disease

Back Pain

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHBack Pain
3
Publications
24
Clinical trials
1
Related conditions
2026
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism-Based Recommendations.

Research2026-01-01Pain practice : the official journal of World Institute of Pain

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q3 2027.
  • Active recent publication activity, including 1 notable finding.
  • 2 industry developments reported.
Upcoming Milestones
Research Highlights1View
Clinical Milestones8View
Results posted 1
Results expected 4
Recently completed 2
Other updates 1
Industry & Market2View
Activity timeline11

Clinical trials

17 sponsors · 1 new · 2 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Ultrasound-guided Erector Spinae Plane (ESP) Block Versus Trigger Point Injection (TPI) for Chronic Thoracic Myofascial Pain: A Randomized Controlled Trial

Phase 4 · Recruiting · Mayo Clinic

Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

Phase 4 · Recruiting · Montefiore Medical Center

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Phase 3 · Recruiting · Eli Lilly and Company

Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial

Phase 3 · Recruiting · Bart Koes

Integrating Tailored Postoperative Opioid Tapering and Pain Management Support for Patients on Long-Term Opioid Use Presenting for Surgery

Phase 3 · Recruiting · Stanford University

Melatonin for Patients With Chronic Low Back Pain - a Randomized Placebo-controlled Trial

Phase 3 · Recruiting · Bart Koes
Recruiting

Ultrasound-guided Erector Spinae Plane (ESP) Block Versus Trigger Point Injection (TPI) for Chronic Thoracic Myofascial Pain: A Randomized Controlled Trial

Phase 4 · Recruiting · Mayo Clinic

Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

Phase 4 · Recruiting · Montefiore Medical Center

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

Phase 3 · Recruiting · Eli Lilly and Company

Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial

Phase 3 · Recruiting · Bart Koes

Integrating Tailored Postoperative Opioid Tapering and Pain Management Support for Patients on Long-Term Opioid Use Presenting for Surgery

Phase 3 · Recruiting · Stanford University

Melatonin for Patients With Chronic Low Back Pain - a Randomized Placebo-controlled Trial

Phase 3 · Recruiting · Bart Koes
Recently completed

Melatonin fOr CHronic bAck Pain (The MOCHA Trial): A Randomized, Double Blind, Placebo-controlled Trial

Phase 3 · Completed · Odense University Hospital

Efficacy and Safety of the Fixed-Dose Combination of Etoricoxib / Tizanidine Versus Etoricoxib in the Treatment of Patients With Acute Low Back Pain Associated to Muscle Spasm

Phase 3 · Completed · Laboratorios Silanes S.A. de C.V.

Investigating Dry Needling as an Add-on Therapy to Conventional Treatment for Myofascial Low Back Pain: A Randomized Controlled Trial

Phase 4 · Completed · Dr. Vishwanath Karad MIT World Peace University

A Randomized, Double-blind, Active-controlled, Non-inferiority, Multicenter Phase III Study to Evaluate the Efficacy and Safety of HCP1004 as Compared to RLD2401 in Chronic Low-Back Pain Patients

Phase 3 · Completed · Hanmi Pharmaceutical Company Limited

University of Michigan Mechanistic Research Center -The Back Pain Consortium Research Program

Phase 4 · Completed · University of Michigan

The Efficacy of Dexketoprofen And Methylprednisolone in the Acute Low Back Pain

Phase 4 · Completed · Ali Gur

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20042026
Major themes2
  • Back Pain1
  • Failed Back Surgery Syndrome1
Leading journals3
  • Neurosurgery1
  • Pain practice : the official journal of World Institute of Pain1
  • The Journal of neuroscience : the official journal of the Society for Neuroscience1
Leading researchers8
  • Amirdelfan K1
  • Apkarian AV1
  • Barolat G1
  • Benyamin R1
  • Bundschu R1
  • Burgher AH1
  • Doust MW1
  • Duarte RV1
Affiliations (unnormalised)6
  • *Center for Clinical Research and Carolina's Pain Institute1
  • Center of Pain Medicine1
  • Cleveland Clinic1
  • Department of Physiology and Institute of Neuroscience1
  • Johns Hopkins University School of Medicine1
  • Pain & Neuromodulation Centre1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Failed Back Surgery Syndrome2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.

Identifiers
MeSHBack Pain
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.