Back to discover
Disease

Failed Back Surgery Syndrome

Late-stage therapeutic developmentEmerging research
MeSHFailed Back Surgery Syndrome
2
Publications
8
Clinical trials
1
Related conditions
2026
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism-Based Recommendations.

Research2026-01-01Pain practice : the official journal of World Institute of Pain

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • Active recent publication activity, including 1 notable finding.
  • 1 clinical trial with recent milestones (1 completed or reporting results).
Major developments
Notable research publicationWorth watching
The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism-Based Recommendations.
Thomson S · 20262026-01-01
Research Highlights1View
Clinical Milestones1View
Recently completed 1
Activity timeline2

Clinical trials

6 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
8
All trials
0
Active
4
Late-stage
6
Completed
Recently completed

Prospective Comparative Study of Epiduroscopic Adhesiolysis in Patients With Failed Back Surgery Syndrome and Patients Without Prior Lumbar Surgery

N/A · Completed · EPC Education s.r.o.

Pulsed Epidural Radiofrequency Versus Epidural Steroid Injection in Patients With Failed Back Syndrome

N/A · Completed · Puerta de Hierro University Hospital

Pregabalin Versus Gabapentin Efficacy in the Management of Neuropathic Pain Associated With Failed Back Surgery Syndrome

Phase 4 · Completed · Al-Kindy College of Medicine

A Randomized Double Blind Cross-over Trial of Continuous Intrathecal Infusion for Assessing Patients With Chronic Non-cancer Pain Who Would Benefit From Treatment With Intrathecal Drug Delivery System (IDDS) Implant

Phase 4 · Completed · University Hospitals Cleveland Medical Center

Prospective, Randomized Study of Multicolumn Implantable Lead Stimulation for Predominant Low Back Pain

Phase 4 · Completed · MedtronicNeuro

Efficacy of Pregabalin in Patients With Radicular Pain

Phase 4 · Completed · Northwestern University

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20162026
Major themes2
  • Back Pain1
  • Failed Back Surgery Syndrome1
Leading journals2
  • Neurosurgery1
  • Pain practice : the official journal of World Institute of Pain1
Leading researchers8
  • Amirdelfan K1
  • Barolat G1
  • Benyamin R1
  • Bundschu R1
  • Burgher AH1
  • Doust MW1
  • Duarte RV1
  • Gliner BE1
Affiliations (unnormalised)6
  • *Center for Clinical Research and Carolina's Pain Institute1
  • Center of Pain Medicine1
  • Cleveland Clinic1
  • Johns Hopkins University School of Medicine1
  • Pain & Neuromodulation Centre1
  • Presbyterian/St Lukes Medical Center1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Back Pain2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition of persistent pain and discomfort in the BACK and the LEG following lumbar surgery, often seen in patients enrolled in pain centers.

Identifiers
MeSHFailed Back Surgery Syndrome
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.