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Disease

Burnout, Professional

Late-stage therapeutic developmentEmerging researchSteady momentum
6
Publications
4
Clinical trials
1
Related conditions
2022
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Stress, Burnout, Anxiety and Depression among Teachers: A Scoping Review.

Research2022-08-27International journal of environmental research and public health

Burnout: A Review of Theory and Measurement.

Research2022-02-04International journal of environmental research and public health

Burnout Assessment Tool (BAT)-Development, Validity, and Reliability.

Research2020-12-18International journal of environmental research and public health

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Clinical trials

4 sponsors · 2 new · 1 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Research activity

6 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20182022
Most influential

Burnout: A Review of Theory and Measurement.

International journal of environmental research and public health · 2022 · 316 cites

Burnout Assessment Tool (BAT)-Development, Validity, and Reliability.

International journal of environmental research and public health · 2020 · 289 cites

Stress, Burnout, Anxiety and Depression among Teachers: A Scoping Review.

International journal of environmental research and public health · 2022 · 162 cites
Recent publications

Burnout: A Review of Theory and Measurement.

International journal of environmental research and public health · 2022 · 316 cites

Stress, Burnout, Anxiety and Depression among Teachers: A Scoping Review.

International journal of environmental research and public health · 2022 · 162 cites

Burnout Assessment Tool (BAT)-Development, Validity, and Reliability.

International journal of environmental research and public health · 2020 · 289 cites
Major themes5
  • Burnout, Professional3
  • COVID-192
  • Depression1
  • Nurses1
  • Resilience, Psychological1
Leading journals3
  • International journal of environmental research and public health4
  • JAMA1
  • Journal of advanced nursing1
Leading researchers8
  • Agyapong B1
  • Bilali A1
  • Burback L1
  • De Witte H1
  • Desart S1
  • Edú-Valsania S1
  • Fragkou D1
  • Galanis P1
Affiliations (unnormalised)6
  • Brigham and Women's Hospital1
  • Brigham Education Institute1
  • Center for Health Services Management and Evaluation1
  • Complutense University of Madrid1
  • Harvard Medical School1
  • Hospital Waste Management Unit1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Disease profile

A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.

Overview

Professional burnout is an occupational phenomenon caused by excessive stress in the work environment. It is characterized by emotional and physical exhaustion, along with feelings of frustration and failure. The literature frames it as a job-related syndrome studied in relation to psychology and occupational health.

Causes

The grounding supports chronic workplace stress as the central cause of professional burnout. Reviews also describe triggering factors in the work environment and individual factors that may modulate burnout. No more specific aetiology is supported here.

Pathophysiology

Burnout is described as developing through chronic stress in the workplace and is commonly discussed as having dimensions such as emotional exhaustion, depersonalization, and reduced personal accomplishment. The literature also links it with psychological outcomes and co-studied conditions such as anxiety and depression. Beyond this syndrome-level description, the grounding does not support a more specific biological mechanism.

Risk factors

The grounding supports occupational stress and adverse work-environment factors as risk factors for burnout. It also indicates that individual factors may modulate susceptibility. In specific occupational groups studied in the reviews, burnout is associated with the professional context itself, but no broader risk-factor list is supported.

Current standard of care

The literature describes prevention and reduction strategies rather than a single disease-specific treatment. These are discussed at the modality level as actions to prevent and/or reduce burnout, alongside measurement tools used to assess it. No specific drug-class treatment is supported by the grounding.

AI-generated summary grounded in MeSH and 4 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An excessive stress reaction to one's occupational or professional environment. It may be characterized by feelings of emotional and physical exhaustion, coupled with a sense of frustration and failure.

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.