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Disease

Chordoma

Active therapeutic pipelineEmerging research
MeSHChordoma
1
Publications
15
Clinical trials
9
Associated genes
1
Related proteins
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q2 2027.
Upcoming Milestones
Clinical Milestones4View
Results posted 1
Results expected 2
Recently completed 1
Activity timeline4

Clinical trials

15 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
15
All trials
6
Active
0
Late-stage
6
Completed
Recently completed

A Phase 2, Single Arm, European Multi-center Trial Evaluating the Efficacy of Afatinib As First-line or Later-line Treatment in Advanced Chordoma.

Phase 2 · Completed · Leiden University Medical Center

Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers

Phase 2 · Completed · Institut Curie

A Signal Finding Phase 2 Study of Nivolumab (Anti-PD-1; BMS-936558; ONO-4538) and Relatlimab (Anti-LAG-3 Monoclonal Antibody; BMS-986016) in Patients With Advanced Chordoma

Phase 2 · Completed · Jonsson Comprehensive Cancer Center

CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma (NCT-PMO-1601)

Phase 2 · Completed · University Hospital Heidelberg

A Phase 2 Trial of BN-Brachyury and Radiation Therapy in Patients With Advanced Chordoma

Phase 2 · Completed · Bavarian Nordic

A Randomized, Double-Blind, Phase 2 Trial of GI-6301 (Yeast-Brachyury Vaccine) Versus Placebo in Combination With Standard of Care Definitive Radiotherapy in Locally Advanced, Unresectable, Chordoma

Phase 2 · Completed · NantCell, Inc.

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Chordoma: Genetics and Contemporary Management.

International journal of molecular sciences · 2024 · 15 cites
Recent publications

Chordoma: Genetics and Contemporary Management.

International journal of molecular sciences · 2024 · 15 cites
Major themes1
  • Chordoma1
Leading journals1
  • International journal of molecular sciences1
Leading researchers3
  • Desai R1
  • Dunn IF1
  • Pelargos PE1
Affiliations (unnormalised)1
  • University of Oklahoma1

Associated genes

9 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

TBXT0.39TFE30.37SSX20.37ASPSCR10.37GMFG0.07IER20.04DUSP120.03GLYATL20.01POLR3C0.01

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

T-box transcription factor Tvia TBXT0.39

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)

Identifiers
MeSHChordoma
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.