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Disease

Chordoma

Active therapeutic pipelineEmerging research
MeSHChordoma
1
Publications
15
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Chordoma: Genetics and Contemporary Management.

Research2024-05-28International journal of molecular sciences

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Clinical Milestones4View
Results expected 3
Recently completed 1
Activity timeline4

Clinical trials

15 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
15
All trials
6
Active
0
Late-stage
6
Completed
Recently completed

A Phase 2, Single Arm, European Multi-center Trial Evaluating the Efficacy of Afatinib As First-line or Later-line Treatment in Advanced Chordoma.

Phase 2 · Completed · Leiden University Medical Center

Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers

Phase 2 · Completed · Institut Curie

A Signal Finding Phase 2 Study of Nivolumab (Anti-PD-1; BMS-936558; ONO-4538) and Relatlimab (Anti-LAG-3 Monoclonal Antibody; BMS-986016) in Patients With Advanced Chordoma

Phase 2 · Completed · Jonsson Comprehensive Cancer Center

CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma (NCT-PMO-1601)

Phase 2 · Completed · University Hospital Heidelberg

A Phase 2 Trial of BN-Brachyury and Radiation Therapy in Patients With Advanced Chordoma

Phase 2 · Completed · Bavarian Nordic

A Randomized, Double-Blind, Phase 2 Trial of GI-6301 (Yeast-Brachyury Vaccine) Versus Placebo in Combination With Standard of Care Definitive Radiotherapy in Locally Advanced, Unresectable, Chordoma

Phase 2 · Completed · NantCell, Inc.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Chordoma: Genetics and Contemporary Management.

International journal of molecular sciences · 2024 · 15 cites
Recent publications

Chordoma: Genetics and Contemporary Management.

International journal of molecular sciences · 2024 · 15 cites
Major themes1
  • Chordoma1
Leading journals1
  • International journal of molecular sciences1
Leading researchers3
  • Desai R1
  • Dunn IF1
  • Pelargos PE1
Affiliations (unnormalised)1
  • University of Oklahoma1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A malignant tumor arising from the embryonic remains of the notochord. It is also called chordocarcinoma, chordoepithelioma, and notochordoma. (Dorland, 27th ed)

Identifiers
MeSHChordoma
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.