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Disease
Cleft Lip
Late-stage therapeutic developmentEmerging research
1
Publications
13
Clinical trials
2023
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Orofacial Clefts: Genetics of Cleft Lip and Palate.
Research2023-08-09Genes
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 3 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
- Q3 2026Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate Surgery
- Q1 2027Ketorolac in Palatoplasty: A Randomized Blinded Controlled Trial.
- Q1 2028Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical Trial
Major developments
Upcoming trial readoutImportant
Results expected Q1 20282026-02-19
Upcoming trial readoutImportant
Results expected Q1 20272026-02-19
Clinical MilestonesViewHide
Results expected
- 2026-04-29Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate SurgeryResults expected Q3 2026
- 2026-02-19Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical TrialResults expected Q1 2028
- 2026-02-19Ketorolac in Palatoplasty: A Randomized Blinded Controlled Trial.Results expected Q1 2027
Recently completed
- 2026-05-01Efficacy of Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy: A Randomized Controlled Clinical Trial.Primary completion
- 2026-04-24Liposomal Bupivacaine Use in Alveolar Bone Graft PatientsPrimary completion
Activity timeline5
- 2026-05-01ClinicalEfficacy of Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy: A Randomized Controlled Clinical Trial.Primary completion
- 2026-04-29ClinicalComparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate SurgeryResults expected Q3 2026
- 2026-04-24ClinicalLiposomal Bupivacaine Use in Alveolar Bone Graft PatientsPrimary completion
- 2026-02-19ClinicalCost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical TrialResults expected Q1 2028
- 2026-02-19ClinicalKetorolac in Palatoplasty: A Randomized Blinded Controlled Trial.Results expected Q1 2027
Clinical trials
The current development programme across all trial phases.
Clinical programme
13
6
8
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Most influential
Recent publications
Major themes2
- Cleft Lip1
- Cleft Palate1
Leading journals1
- Genes1
Leading researchers2
- Babai A1
- Irving M1
Affiliations (unnormalised)1
- Department of Clinical Genetics1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.