Cleft Lip
Recent clinical, regulatory, research and industry developments relating to this disease.
Orofacial Clefts: Genetics of Cleft Lip and Palate.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 3 clinical trials expected to report results, the earliest in Q1 2027.
- Q1 2027Ketorolac in Palatoplasty: A Randomized Blinded Controlled Trial.
- Q1 2028Comparison of Intramuscular Ketamine and Intranasal Nalbuphine and Dexmedetomidine for Analgosedation in Children Undergoing Suture Removal After Surgery for Congenital Clefts of the Palate, Alveolar Ridge, and Lip
- Q1 2028Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical Trial
Clinical MilestonesViewHide
- 2026-02-19Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical TrialResults expected Q1 2028
- 2026-02-19Ketorolac in Palatoplasty: A Randomized Blinded Controlled Trial.Results expected Q1 2027
- 2026-01-14Comparison of Intramuscular Ketamine and Intranasal Nalbuphine and Dexmedetomidine for Analgosedation in Children Undergoing Suture Removal After Surgery for Congenital Clefts of the Palate, Alveolar Ridge, and LipResults expected Q1 2028
- 2026-08-30Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate SurgeryPrimary completion
- 2026-05-01Efficacy of Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy: A Randomized Controlled Clinical Trial.Completed
- 2026-04-24Liposomal Bupivacaine Use in Alveolar Bone Graft PatientsPrimary completion
- 2026-08-30ClinicalComparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate SurgeryPrimary completion
- 2026-05-01ClinicalEfficacy of Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy: A Randomized Controlled Clinical Trial.Completed
- 2026-04-24ClinicalLiposomal Bupivacaine Use in Alveolar Bone Graft PatientsPrimary completion
- 2026-02-19ClinicalCost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical TrialResults expected Q1 2028
- 2026-02-19ClinicalKetorolac in Palatoplasty: A Randomized Blinded Controlled Trial.Results expected Q1 2027
- 2026-01-14ClinicalComparison of Intramuscular Ketamine and Intranasal Nalbuphine and Dexmedetomidine for Analgosedation in Children Undergoing Suture Removal After Surgery for Congenital Clefts of the Palate, Alveolar Ridge, and LipResults expected Q1 2028
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes2
- Cleft Lip1
- Cleft Palate1
Leading journals1
- Genes1
Leading researchers2
- Babai A1
- Irving M1
Affiliations (unnormalised)1
- Department of Clinical Genetics1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.