Back to discover
Disease

Cleft Palate

Late-stage therapeutic developmentEmerging research
MeSHCleft Palate
1
Publications
13
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Evaluation of Trigeminal Nerve Blockade in the Pterygopalatine Fossa for Cleft Palate Repair: a Pilot Study
Results expected Q2 20272026-07-21
Upcoming trial readoutHigh impact
Perioperative Methadone Use for Cleft Palate Repair: A Randomized Controlled Trial
Results expected Q2 20272026-04-14
Clinical Milestones4View
Results expected 3
Recently completed 1
Activity timeline4

Clinical trials

10 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
13
All trials
3
Active
9
Late-stage
6
Completed
Late-stage studies

Evaluation of Trigeminal Nerve Blockade in the Pterygopalatine Fossa for Cleft Palate Repair: a Pilot Study

Phase 4 · Active, not recruiting · University of Florida

Perioperative Methadone Use for Cleft Palate Repair: A Randomized Controlled Trial

Phase 4 · Recruiting · Duke University

Preemptive Nebulized Bupivacaine for Pain Control After Cleft Palate Repair in Children: A Randomized Double Blind Controlled Trial

Phase 3 · Recruiting · Assiut University

Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery

Phase 2/3 · Completed · Assiut University

Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty : Randomized Study

Phase 4 · Completed · Professor Fernando Figueira Integral Medicine Institute

Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants

Phase 4 · Completed · Institute of Child Health
Recently completed

Optic Nerve Sheath Diameter (ONSD): A New Modality to Assess Postoperative Agitation After a Single Bolus of Dexmedetomidine Versus Normal Saline in Children With Cleft Palate Repair

Phase 3 · Completed · Assiut University

Evaluation of Postoperative Analgesic Effects of Bilateral Suprazygomatic Maxillary Nerve Block Using Bupivacaine and Dexmedetomidine in Children Undergoing Cleft Palate Repair Under General Anesthesia:Randomized Controlled Trial

Phase 2 · Completed · Assiut University

Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery

Phase 2/3 · Completed · Assiut University

Cell Therapy for Craniofacial Bone Defects

Phase 1/2 · Completed · University of Michigan

Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty : Randomized Study

Phase 4 · Completed · Professor Fernando Figueira Integral Medicine Institute

Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants

Phase 4 · Completed · Institute of Child Health

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Orofacial Clefts: Genetics of Cleft Lip and Palate.

Genes · 2023 · 56 cites
Recent publications

Orofacial Clefts: Genetics of Cleft Lip and Palate.

Genes · 2023 · 56 cites
Major themes2
  • Cleft Lip1
  • Cleft Palate1
Leading journals1
  • Genes1
Leading researchers2
  • Babai A1
  • Irving M1
Affiliations (unnormalised)1
  • Department of Clinical Genetics1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Congenital fissure of the soft and/or hard palate, due to faulty fusion.

Identifiers
MeSHCleft Palate
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.