Cleft Palate
Recent clinical, regulatory, research and industry developments relating to this disease.
Orofacial Clefts: Genetics of Cleft Lip and Palate.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q2 2027.
Clinical MilestonesViewHide
- 2026-07-21Evaluation of Trigeminal Nerve Blockade in the Pterygopalatine Fossa for Cleft Palate Repair: a Pilot StudyResults expected Q2 2027
- 2026-04-14Perioperative Methadone Use for Cleft Palate Repair: A Randomized Controlled TrialResults expected Q2 2027
- 2026-08-10Preemptive Nebulized Bupivacaine for Pain Control After Cleft Palate Repair in Children: A Randomized Double Blind Controlled TrialPrimary completion
- 2026-03-20Optic Nerve Sheath Diameter (ONSD): A New Modality to Assess Postoperative Agitation After a Single Bolus of Dexmedetomidine Versus Normal Saline in Children With Cleft Palate RepairCompleted
- 2026-08-10ClinicalPreemptive Nebulized Bupivacaine for Pain Control After Cleft Palate Repair in Children: A Randomized Double Blind Controlled TrialPrimary completion
- 2026-07-21ClinicalEvaluation of Trigeminal Nerve Blockade in the Pterygopalatine Fossa for Cleft Palate Repair: a Pilot StudyResults expected Q2 2027
- 2026-04-14ClinicalPerioperative Methadone Use for Cleft Palate Repair: A Randomized Controlled TrialResults expected Q2 2027
- 2026-03-20ClinicalOptic Nerve Sheath Diameter (ONSD): A New Modality to Assess Postoperative Agitation After a Single Bolus of Dexmedetomidine Versus Normal Saline in Children With Cleft Palate RepairCompleted
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes2
- Cleft Lip1
- Cleft Palate1
Leading journals1
- Genes1
Leading researchers2
- Babai A1
- Irving M1
Affiliations (unnormalised)1
- Department of Clinical Genetics1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Congenital fissure of the soft and/or hard palate, due to faulty fusion.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.