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Disease

Corneal Neovascularization

Late-stage therapeutic developmentEmerging research
1
Publications
12
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Genome Editing VEGFA Prevents Corneal Neovascularization In Vivo.

Research2024-04-06Advanced science (Weinheim, Baden-Wurttemberg, Germany)

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Major developments
Upcoming trial readoutImportant
Results expected Q4 20262026-01-09
Clinical Milestones1View
Activity timeline1

Clinical trials

10 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
12
All trials
1
Active
2
Late-stage
6
Completed
Late-stage studies

The Effect of Bevacizumab on Corneal Neovascularization

Phase 4 · Completed · Instituto de Olhos de Goiania
Recruiting

Clinical Study of Intrastromal Anti-VEGF Injection for Corneal Neovascularization.

Phase 1/2 · Recruiting · Second Affiliated Hospital, School of Medicine, Zhejiang University
Recently completed

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Genome Editing VEGFA Prevents Corneal Neovascularization In Vivo.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024 · 17 cites
Recent publications

Genome Editing VEGFA Prevents Corneal Neovascularization In Vivo.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024 · 17 cites
Major themes5
  • Corneal Neovascularization1
  • CRISPR-Cas Systems1
  • Gene Editing1
  • Human Umbilical Vein Endothelial Cells1
  • Vascular Endothelial Growth Factor A1
Leading journals1
  • Advanced science (Weinheim, Baden-Wurttemberg, Germany)1
Leading researchers8
  • Chen L1
  • Chen X1
  • Chen Z1
  • Huang J1
  • Lei H1
  • Li S1
  • Lin M1
  • McAlinden C1
Affiliations (unnormalised)6
  • 2nd Affiliated Hospital of Nanchang University1
  • Eye Institute and Department of Ophthalmology1
  • Key Laboratory for Regenerative Medicine1
  • Queen Victoria Hospital1
  • School of Ophthalmology and Optometry and Eye Hospital1
  • Shanghai Key Laboratory of Visual Impairment and Restoration1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.