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RNGTT

Gene

RNA guanylyltransferase and 5'-phosphatase

HGNCHGNC:10073EnsemblENSG00000111880NCBI Gene8732
Locus: gene with protein productLocation: 6q15

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHCE · HCE1 · hCAP
View full nomenclature history (6)
Alias symbolsHCE, HCE1, hCAP
Alias namesmRNA guanylyltransferase, mRNA 5'-triphosphate monophosphatase, mRNA-capping enzyme

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
HIV Infections
Autoimmune disorder of central nervous system
Liver Diseases
Corneal Neovascularization
Systemic Inflammatory Response Syndrome
Alcohol drinking
Urolithiasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Atypical dual specificity phosphatases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-10-10.
Open TargetsGene–disease associations from the Open Targets Platform.