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Disease

Corneal Ulcer

Late-stage therapeutic developmentEmerging research
MeSHCorneal Ulcer
1
Publications
12
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A
Results expected Q3 20272026-06-05
Major trial resultsImportant
Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers
Results posted2025-09-25
Clinical Milestones4View
Results posted 1
Results expected 2
Recently completed 1
Activity timeline4

Clinical trials

8 sponsors · 2 new · 0 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
12
All trials
3
Active
7
Late-stage
6
Completed
Late-stage studies

Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A

Phase 3 · Recruiting · University of California, San Francisco

Cross-linking for Corneal Ulcers Treatment Trial

Phase 3 · Completed · University of California, San Francisco

Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers

Phase 3 · Completed · University of California, San Francisco

The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo

Phase 3 · Completed · University of California, San Francisco

Steroids for Corneal Ulcers Trial

Phase 4 · Completed · Thomas M. Lietman

Mycotic Ulcer Treatment Trial

Phase 3 · Completed · University of California, San Francisco
Recruiting

Efficacy of Locally Delivered Allogeneic Mesenchymal Stem Cells for Promoting Corneal Repair

Phase 2 · Recruiting · University of Illinois at Chicago

Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A

Phase 3 · Recruiting · University of California, San Francisco

Intrastromal Moxifloxacin as an Adjunctive Therapy in Recalcitrant Bacterial Keratitis

N/A · Recruiting · Minia University
Recently completed

Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers

Phase 3 · Completed · University of California, San Francisco

Cross-linking for Corneal Ulcers Treatment Trial

Phase 3 · Completed · University of California, San Francisco

The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo

Phase 3 · Completed · University of California, San Francisco

Mycotic Ulcer Treatment Trial

Phase 3 · Completed · University of California, San Francisco

Steroids for Corneal Ulcers Trial

Phase 4 · Completed · Thomas M. Lietman

A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers

Phase 2 · Completed · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes3
  • Corneal Ulcer1
  • Eye Infections, Bacterial1
  • Keratitis1
Leading journals1
  • Indian journal of ophthalmology1
Leading researchers7
  • Ambastha A1
  • Arya LK1
  • Kumari A1
  • Kumari N1
  • Kusumesh R1
  • Mohan N1
  • Sinha BP1
Affiliations (unnormalised)2
  • Department of Microbiology Indira Gandhi Institute of Medical Sciences1
  • Regional Institute of Ophthalmology1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.

Identifiers
MeSHCorneal Ulcer
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.