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Disease

Deafness

Late-stage therapeutic development
Also known as Bilateral Deafness, Bilateral deafness (finding), Complete deafness (finding), Deafness NOS+4 more

Bilateral Deafness, Bilateral deafness (finding), Complete deafness (finding), Deafness NOS, Deafness NOS (disorder), Deafness NOS (finding), Total Deafness, complete hearing loss.

18
Clinical trials
12
Associated genes
3
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 4 clinical trials expected to report results, the earliest in Q1 2027.
  • 3 industry developments reported.
Upcoming Milestones
Clinical Milestones5View
Results expected 4
Recently completed 1
Industry & Market3View
Activity timeline8

Clinical trials

17 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
4
Late-stage
6
Completed
Late-stage studies

A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group, Pivotal Trial to Assess the Efficacy and Safety of Sonlicromanol in Adult Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Variant

Phase 3 · Recruiting · Khondrion BV

Sudden Hearing Loss Multicenter Treatment Trial

Phase 3 · Completed · Massachusetts Eye and Ear Infirmary

The Evaluation of the Effectiveness of Bone-anchored Hearing Aids (Baha) in Patients With Conductive or Mixed Hearing Loss, or Unilateral Deafness

Phase 4 · Withdrawn · University Hospital, Ghent

A Prospective, Randomized, Double Blind, Placebo Controlled, Multicenter Study on the Safety and Efficacy of Continuous Infusion of Corticosteroid Delivered Via Catheter in Patients With Idiopathic Sudden Sensorineural Hearing Loss

Phase 3 · Completed · University Hospital Tuebingen
Recruiting

A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group, Pivotal Trial to Assess the Efficacy and Safety of Sonlicromanol in Adult Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Variant

Phase 3 · Recruiting · Khondrion BV

A Phase 1b/2a, Double-blinded, Placebo-controlled, Multiple Doses, 2 Step-up Study Evaluating the Safety, Tolerability, PK/PD and Efficacy of Systemic NS101 in Healthy Volunteers and SSNHL Patients

Phase 1/2 · Recruiting · Neuracle Science Co., LTD.

Cochlear Implantation in Infants and Toddlers With Single-Sided Deafness

N/A · Recruiting · University of North Carolina, Chapel Hill

A Post-approval, Prospective, Nonrandomized, Single-arm Multicenter Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness

N/A · Recruiting · Cochlear

Novel Coding Strategies for Children With Cochlear Implants

N/A · Recruiting · NYU Langone Health
Recently completed

Cochlear Implantation in Cases of Single-Sided Deafness

N/A · Completed · University of North Carolina, Chapel Hill

A Feasibility Study of the Placement, Use, and Safety of the Nucleus 24 Auditory Brainstem Implant in Non-Neurofibromatosis Type 2 (NF2) Pediatric Patients

Phase 1 · Completed · Laurie Eisenberg

OUTCOMES IN CHILDREN WITH DEVELOPMENTAL DELAY AND DEAFNESS: A PROSPECTIVE, RANDOMIZED TRIAL

Phase 1 · Completed · Stanford University

Balance in Children With Cochlear Implants

Early Phase 1 · Completed · University of Oklahoma

Sudden Hearing Loss Multicenter Treatment Trial

Phase 3 · Completed · Massachusetts Eye and Ear Infirmary

A Prospective, Randomized, Double Blind, Placebo Controlled, Multicenter Study on the Safety and Efficacy of Continuous Infusion of Corticosteroid Delivered Via Catheter in Patients With Idiopathic Sudden Sensorineural Hearing Loss

Phase 3 · Completed · University Hospital Tuebingen

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

MYO7A0.74CDH230.72OTOF0.71GJB20.71TBC1D240.68TMC10.68PNPT10.68MYO15A0.66CABP20.66EPS8L20.65CIB20.65CDC14A0.64

Disease biology

3 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Tenascinvia TNC0.55Sphingosine 1-phosphate receptor 2via S1PR20.53Hepatocyte growth factorvia HGF0.39

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A general term for the complete loss of the ability to hear from both ears.

Synonyms

Bilateral Deafness, Bilateral deafness (finding), Complete deafness (finding), Deafness NOS, Deafness NOS (disorder), Deafness NOS (finding), Total Deafness, complete hearing loss

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.