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Disease
Deafness
Late-stage therapeutic development
Also known as Bilateral Deafness, Bilateral deafness (finding), Complete deafness (finding), Deafness NOS+4 more
Bilateral Deafness, Bilateral deafness (finding), Complete deafness (finding), Deafness NOS, Deafness NOS (disorder), Deafness NOS (finding), Total Deafness, complete hearing loss.
18
Clinical trials
12
Associated genes
3
Related proteins
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 5 clinical trials expected to report results, the earliest in Q1 2027.
- 2 industry developments reported.
Upcoming Milestones
- Q1 2027Novel Coding Strategies for Children With Cochlear Implants
- Q1 2027Stimulating the Cochlear Apex Without Longer Electrodes
- Q2 2027A Phase II, Randomized Trial of Intratympanic Drug Delivery: Evaluating the Efficacy and Safety of Dexamethasone-Loaded Exosomes Versus Standard Therapy in Acute Sensorineural Hearing Loss.
- Q2 2027A Post-approval, Prospective, Nonrandomized, Single-arm Multicenter Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness
- Q2 2030Cochlear Implantation in Infants and Toddlers With Single-Sided Deafness
Major developments
Upcoming trial readoutImportant
Results expected Q2 20302026-06-26
Upcoming trial readoutImportant
Results expected Q2 20272026-05-05
Clinical MilestonesViewHide
Results posted
Results expected
- 2026-06-26Cochlear Implantation in Infants and Toddlers With Single-Sided DeafnessResults expected Q2 2030
- 2026-05-05A Phase II, Randomized Trial of Intratympanic Drug Delivery: Evaluating the Efficacy and Safety of Dexamethasone-Loaded Exosomes Versus Standard Therapy in Acute Sensorineural Hearing Loss.Results expected Q2 2027
- 2026-03-06Stimulating the Cochlear Apex Without Longer ElectrodesResults expected Q1 2027
- 2026-03-04Novel Coding Strategies for Children With Cochlear ImplantsResults expected Q1 2027
- 2025-09-02A Post-approval, Prospective, Nonrandomized, Single-arm Multicenter Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided DeafnessResults expected Q2 2027
Industry & MarketViewHide
- 2026-08-11STAT+: Skylark Bio kicks off new gene therapy trial for deafnessTrial news · STAT News
- 2026-04-03Deafness reversed: One injection restores hearing in just weeksIndustry · Science Daily
Activity timeline9
- 2026-08-11IndustrySTAT+: Skylark Bio kicks off new gene therapy trial for deafnessTrial news · STAT News
- 2026-06-26ClinicalCochlear Implantation in Infants and Toddlers With Single-Sided DeafnessResults expected Q2 2030
- 2026-05-31ClinicalA Phase 1b/2a, Double-blinded, Placebo-controlled, Multiple Doses, 2 Step-up Study Evaluating the Safety, Tolerability, PK/PD and Efficacy of Systemic NS101 in Healthy Volunteers and SSNHL PatientsPrimary completion
- 2026-05-05ClinicalA Phase II, Randomized Trial of Intratympanic Drug Delivery: Evaluating the Efficacy and Safety of Dexamethasone-Loaded Exosomes Versus Standard Therapy in Acute Sensorineural Hearing Loss.Results expected Q2 2027
- 2026-04-03IndustryDeafness reversed: One injection restores hearing in just weeksIndustry · Science Daily
- 2026-03-06ClinicalStimulating the Cochlear Apex Without Longer ElectrodesResults expected Q1 2027
- 2026-03-04ClinicalNovel Coding Strategies for Children With Cochlear ImplantsResults expected Q1 2027
- 2025-09-15ClinicalA Feasibility Study of the Placement, Use, and Safety of the Nucleus 24 Auditory Brainstem Implant in Non-Neurofibromatosis Type 2 (NF2) Pediatric PatientsResults posted
- 2025-09-02ClinicalA Post-approval, Prospective, Nonrandomized, Single-arm Multicenter Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided DeafnessResults expected Q2 2027
Clinical trials
The current development programme across all trial phases.
Clinical programme
18
6
3
6
Late-stage studies
Recruiting
Recently completed
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
A general term for the complete loss of the ability to hear from both ears.
Synonyms
Bilateral Deafness, Bilateral deafness (finding), Complete deafness (finding), Deafness NOS, Deafness NOS (disorder), Deafness NOS (finding), Total Deafness, complete hearing loss
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Related entities are derived from literature co-mention (studied together) — associative, not causal.