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Disease

Developmental and epileptic encephalopathy, 42

Late-stage therapeutic development
Also known as CACNA1A early infantile epileptic encephalopathy, DEE42, EIEE42, developmental and epileptic encephalopathy 42+4 more

CACNA1A early infantile epileptic encephalopathy, DEE42, EIEE42, developmental and epileptic encephalopathy 42, early infantile epileptic encephalopathy caused by mutation in CACNA1A, epileptic encephalopathy, early infantile, 42, epileptic encephalopathy, early infantile, 42; EIEE42, epileptic encephalopathy, early infantile, type 42.

24
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 5 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones15View all 15
Results posted 3
Results expected 5
Recently completed 4
Other updates 3
+7 more in the activity timeline below
Activity timeline15

Clinical trials

14 sponsors · 3 new · 6 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Randomized Trial of Consolidation Targeted Adjuvant Therapy With Encorafenib and Cetuximab Versus Usual Care for Patients With Stage II/III BRAF V600E Colon Cancer

Phase 2/3 · Active, not recruiting · Alliance for Clinical Trials in Oncology

Phase III Randomized Trial of Immunotherapy With or Without Consolidative Radiotherapy for Oligometastatic Head and Neck Squamous Cell Carcinoma

Phase 3 · Active, not recruiting · ECOG-ACRIN Cancer Research Group

Phase II/III Second-Line NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Mutant Metastatic Pancreatic Ductal Adenocarcinoma (PLATINUM)

Phase 2/3 · Active, not recruiting · Alliance for Clinical Trials in Oncology

A MULTICENTER, OPEN-LABEL, SINGLE-ARM STUDY TO EVALUATE LONG-TERM SAFETY AND TOLERABILITY OF BRIVARACETAM IN STUDY PARTICIPANTS WITH CHILDHOOD ABSENCE EPILEPSY OR JUVENILE ABSENCE EPILEPSY

Phase 3 · Active, not recruiting · UCB Biopharma SRL

Effect of Different Anesthetic Drugs on Electrocorticography (ECOG), Randomized Controlled Double-blinded Study

Phase 3 · Active, not recruiting · Children's Cancer Hospital Egypt 57357

A Randomized Phase 2/3 Study of Olaparib Plus Temozolomide Versus Investigator's Choice for the Treatment of Patients With Advanced Uterine Leiomyosarcoma After Progression on Prior Chemotherapy

Phase 2/3 · Active, not recruiting · National Cancer Institute (NCI)
Recently completed

A Multicenter, Randomized, Double-Blind, Positive-Controlled, Cross-Over Phase Ⅲ Clinical Trial Evaluating the Efficacy and Safety of HRS-9231 for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)

Phase 3 · Completed · Shanghai Shengdi Pharmaceutical Co., Ltd

A Multicenter Open-Label Extension Study to Evaluate the Long-Term Safety of Cenobamate Adjunctive Therapy in Subjects With Primary Generalized Tonic-Clonic Seizures

Phase 3 · Completed · SK Life Science, Inc.

A Multicenter, Randomized, Double-Blind, Positive-Controlled, Cross-Over Phase III Clinical Trial Evaluating the Efficacy and Safety of HRS-9231 for Body Parts (Non-Central Nervous System) Magnetic Resonance Imaging (MRI)

Phase 3 · Completed · Shanghai Shengdi Pharmaceutical Co., Ltd

A Proof-of-concept Clinical Study to Evaluate the Impact of a Combination Nutraceutical Kit on Muscle Function, Cognitive Performance, and Immune Resilience in Older Adults.

Phase 4 · Completed · GPLIFE HEALTHCARE PRIVATE LIMITED

Efficacy of Carboplatin Administered Concomitantly With Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients

Phase 3 · Completed · Children's Oncology Group

Treatment for Very Low and Standard Risk Favorable Histology Wilms Tumor

Phase 3 · Completed · Children's Oncology Group

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

CACNA1A0.81

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Voltage-dependent P/Q-type calcium channel subunit alpha-1Avia CACNA1A0.81

Reference

Authoritative identity, definition & identifiers.

Synonyms

CACNA1A early infantile epileptic encephalopathy, DEE42, EIEE42, developmental and epileptic encephalopathy 42, early infantile epileptic encephalopathy caused by mutation in CACNA1A, epileptic encephalopathy, early infantile, 42, epileptic encephalopathy, early infantile, 42; EIEE42, epileptic encephalopathy, early infantile, type 42

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.