CACNA1A

Gene

calcium voltage-gated channel subunit alpha1 A

HGNCHGNC:1388 EnsemblENSG00000141837 NCBI Gene773

Locus: gene with protein productLocation: 19p13.13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Voltage-dependent P/Q-type calcium channel subunit alpha-1AO00555

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCACNL1A4 · SCA6 · MHP1 · MHP · APCA · Cav2.1 · EA2 · HPCA · FHM

View full nomenclature history (10)

Previous symbolsCACNL1A4, SCA6, MHP1, MHP

Alias symbolsAPCA, Cav2.1, EA2, HPCA, FHM

Previous namescalcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Familial paroxysmal ataxia

Episodic ataxia type 2

Migraine, familial hemiplegic, 1

Developmental and epileptic encephalopathy, 42

Spinocerebellar ataxia type 6

Familial or sporadic hemiplegic migraine

Epilepsy

Neuralgia

Fibromyalgia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Calcium voltage-gated channel alpha1 subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.