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Disease

Fibromyalgia

Late-stage therapeutic developmentEmerging research
MeSHFibromyalgia
4
Publications
24
Clinical trials
1
Related conditions
2024
Latest publication
Current focus
Therapeutic developmentGenetics & risk factorsInflammation & immunity
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 6 clinical trials expected to report results, the earliest in Q1 2027.
  • 1 industry development reported.
Upcoming Milestones
Clinical Milestones16View all 16
Results expected 5
Recently completed 5
Other updates 4
+8 more in the activity timeline below
Industry & Market1View
Activity timeline17

Clinical trials

18 sponsors · 7 new · 6 completed in the last 12 months (net +4)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Randomized Clinical Trial to Evaluate the Efficacy and Safety of Platelet-Rich Plasma (PRP) Injection Combined With Physical Exercise in Chronic Omalgia

Phase 3 · Recruiting · Biobizkaia Health Research Institute

Does the Perioperative Administration of Dexamethasone Increase the Incidence of Chronic Postmastectomy Pain? A Double-blind Randomized Controlled Trial

Phase 4 · Recruiting · McGill University Health Centre/Research Institute of the McGill University Health Centre

A Double-Blind, Placebo-Controlled, Randomized Withdrawal Study to Assess the Efficacy and Safety of AXS-14 in the Management of Fibromyalgia

Phase 3 · Recruiting · Axsome Therapeutics, Inc.

A Randomized, Triple-blind, Placebo-controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Intravenous AMBTX-01 (Neridronate) for Treatment of Complex Regional Pain Syndrome Type 1 (CRPS-RISE)

Phase 3 · Recruiting · Ambros Therapeutics, Inc.

The Efficacy of Ultrasound-guided Bilateral Superficial Cervical Plexus Block on Postoperative Pain Relief in Patients Undergoing Neck Surgeries, Prospective Randomized Controlled Study.

Phase 4 · Active, not recruiting · Sohag University

Fficacy and Safety of Crisugabalin on Nociplastic Pain in Patients With Parkinson's Disease (RELIEF-PD): A Multicentre, Double-Blind, Randomised Controlled Trial

Phase 4 · Active, not recruiting · Guangdong Provincial People's Hospital
Recruiting

Randomized Clinical Trial to Evaluate the Efficacy and Safety of Platelet-Rich Plasma (PRP) Injection Combined With Physical Exercise in Chronic Omalgia

Phase 3 · Recruiting · Biobizkaia Health Research Institute

Does the Perioperative Administration of Dexamethasone Increase the Incidence of Chronic Postmastectomy Pain? A Double-blind Randomized Controlled Trial

Phase 4 · Recruiting · McGill University Health Centre/Research Institute of the McGill University Health Centre

A Double-Blind, Placebo-Controlled, Randomized Withdrawal Study to Assess the Efficacy and Safety of AXS-14 in the Management of Fibromyalgia

Phase 3 · Recruiting · Axsome Therapeutics, Inc.

A Randomized, Triple-blind, Placebo-controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Intravenous AMBTX-01 (Neridronate) for Treatment of Complex Regional Pain Syndrome Type 1 (CRPS-RISE)

Phase 3 · Recruiting · Ambros Therapeutics, Inc.
Recently completed

Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty: A Blinded Randomized Controlled Trial

Phase 3 · Completed · KAZM Pharmaceuticals Inc.

PARASTOP - Paracetamol With Strong Opioids. A Randomized, Double-blind, Parallel-group Non-inferiority Phase III Withdrawal Trial of Paracetamol Versus Placebo in Conjunction With Opioids for Moderate to Severe Cancer-related Pain

Phase 3 · Completed · Oslo University Hospital

Evaluation of the Efficacy of Different Drugs Nebulized at the Glottis on Postoperative Sore Throat in Thyroid Surgery With Nerve Monitoring: a Randomized Controlled Trial

Phase 4 · Completed · Qianfoshan Hospital

Ketamine As Adjuvant to Bupivacaine in Ultrasound Guided Quadratus Lumborum Block for Infants Undergoing Open Pyeloplasty

Phase 4 · Completed · Alexandria University

Ultrasound-Guided Stellate Ganglion Block in Fibromyalgia: A Randomized, Single-Center, Single-Blind, Sham-Controlled Trial

Phase 2/3 · Completed · Sanliurfa Education and Research Hospital

Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery

Phase 3 · Completed · Centre Hospitalier Universitaire, Amiens

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20212024
Major themes4
  • Fibromyalgia2
  • Autoimmune Diseases1
  • Fatigue Syndrome, Chronic1
  • Major Depressive Disorder1
Leading journals4
  • Autoimmunity reviews1
  • International journal of molecular sciences1
  • Scientific reports1
  • The Journal of clinical investigation1
Leading researchers8
  • Algon AAA1
  • Almulla AF1
  • Andersson DA1
  • Baharpoor A1
  • Bevan S1
  • Brieskorn L1
  • Clauw D1
  • Cuhadar U1
Affiliations (unnormalised)6
  • Center of Excellence in Immunology and Immune-Mediated Diseases1
  • Chronic Pain and Fatigue Research Center1
  • Chulalongkorn University1
  • Department of Clinical Neuroscience1
  • Karolinska Institutet1
  • Key Laboratory of Psychosomatic Medicine1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Genetic Predisposition to Disease2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)

Identifiers
MeSHFibromyalgia
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.