SLC6A4

Gene

solute carrier family 6 member 4

HGNCHGNC:11050 EnsemblENSG00000108576 NCBI Gene6532

Locus: gene with protein productLocation: 17q11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium-dependent serotonin transporterP31645

Protein · therapeutic target

Clinically validated target · 53 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHTT · OCD1 · 5-HTT · SERT1

View full nomenclature history (9)

Previous symbolsHTT, OCD1

Alias symbols5-HTT, SERT1

Previous namessolute carrier family 6 (neurotransmitter transporter, serotonin), member 4, 5-hydroxytryptamine (serotonin) transporter, obsessive-compulsive disorder 1, solute carrier family 6 (neurotransmitter transporter), member 4

Alias namesserotonin transporter 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Obsessive-Compulsive Disorder

Major depressive disorder

Stress Disorders, Post-Traumatic

Phobia, Social

Attention Deficit Disorder with Hyperactivity

Bipolar Disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Solute carrier family 6

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.