Stress Disorders, Post-Traumatic

It follows traumatic stressors, but the grounding does not support a more specific aetiology beyond trauma exposure. Genetic variation also contributes to susceptibility, with genome-wide studies indicating heritable risk.

The literature describes PTSD as involving dysregulation of fear acquisition, extinction, and regulation, with the prefrontal cortex and amygdala implicated in threat processing. Additional grounding links traumatic stress to hippocampal structural change and memory-related deficits, and genetic studies suggest polygenic and sex- or ancestry-specific risk architecture.

Exposure to traumatic stressors is the primary risk factor supported by the grounding. Genetic susceptibility also increases risk, and the literature indicates that risk architecture may differ by sex and ancestry.

The supplied grounding supports psychotherapy and other psychological interventions as core treatment modalities. It also includes drug therapy as a literature focus, with co-studied agents such as psilocybin and lysergic acid diethylamide indicating interest in psychedelic-assisted approaches, but it does not support a specific standard drug class beyond that.