Sleep Wake Disorders
Recent clinical, regulatory, research and industry developments relating to this disease.
Relationship Between Sleep and Immunology in Attention Deficit Hyperactivity Disorder.
The night's watch: Exploring how sleep protects against neurodegeneration.
Sleep Problems in Adults With ADHD: Prevalences and Their Relationship With Psychiatric Comorbidity.
Interactions between sleep, inflammation, immunity and infections: A narrative review.
The Role of Sleep in Cardiovascular Disease.
Sleep and cardiovascular disease.
Sleep Deprivation, Sleep Disorders, and Chronic Disease.
Type 2 Diabetes and Its Association With Psychiatric Disorders in Young Adults in South Korea.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- Active recent publication activity.
- 4 clinical trials with recent milestones (1 completed or reporting results).
Research HighlightsViewHide
- 2025-08-18Relationship Between Sleep and Immunology in Attention Deficit Hyperactivity Disorder.Jaromirska J · 2025
Clinical MilestonesViewHide
- 2026-07-01Effect of Holy Qur'an Versus Music Sound on Sleep Quality Among Children Undergoing Chemotherapy: A Randomized Controlled TrialPrimary completion
- 2026-06-01A Multicenter, Double-blind, Randomized Study to Evaluate the Effects of Tasimelteon vs. Placebo in Participants With Delayed Sleep-Wake Phase Disorder (DSWPD)Primary completion
- 2025-12-31The Effectiveness of Lavender Aromatherapy Combined With Slow Breathing Exercises in Improving Occupational Burnout and Sleep Disorders Among Nursing StaffCompleted
- 2025-09-01Clinical Study of Perioperative Sleep Disorders in Cardiac SurgeryPrimary completion
- 2026-07-01ClinicalEffect of Holy Qur'an Versus Music Sound on Sleep Quality Among Children Undergoing Chemotherapy: A Randomized Controlled TrialPrimary completion
- 2026-06-01ClinicalA Multicenter, Double-blind, Randomized Study to Evaluate the Effects of Tasimelteon vs. Placebo in Participants With Delayed Sleep-Wake Phase Disorder (DSWPD)Primary completion
- 2025-12-31ClinicalThe Effectiveness of Lavender Aromatherapy Combined With Slow Breathing Exercises in Improving Occupational Burnout and Sleep Disorders Among Nursing StaffCompleted
- 2025-09-01ClinicalClinical Study of Perioperative Sleep Disorders in Cardiac SurgeryPrimary completion
- 2025-08-18ResearchRelationship Between Sleep and Immunology in Attention Deficit Hyperactivity Disorder.Jaromirska J · 2025
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Sleep Wake Disorders10
- Sleep9
- Mental Disorders3
- Attention Deficit Disorder with Hyperactivity2
- Cardiovascular Diseases2
- Neurodegenerative Diseases2
- Alzheimer Disease1
- Anxiety1
Leading journals6
- Annals of the New York Academy of Sciences1
- BMC medicine1
- BMC psychiatry1
- Critical care medicine1
- Current atherosclerosis reports1
- Emerging topics in life sciences1
Leading researchers8
- Nedergaard M2
- Abdollahi A1
- Abhari FS1
- Abramson M1
- Adjei AA1
- Ahn J1
- Alessio F1
- Altena E1
Affiliations (unnormalised)6
- Mayo Clinic2
- Alexandra Hospital1
- Alice Lee Centre for Nursing Studies1
- Arak University of Medical Sciences1
- Athinoula A. Martinos Center for Biomedical Imaging1
- Austin Hospital and University of Melbourne1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Sleep-wake disorders are abnormalities of the sleep-wake schedule or pattern linked to circadian rhythm disruption. They affect the length, timing, and/or regularity of the sleep-wake cycle relative to the day-night cycle.
The supplied grounding does not identify a specific cause or aetiology for sleep-wake disorders. It does indicate that sleep disruption can be associated with stress, anxiety, depression, mental health problems, aging, and psychological factors.
The grounding supports a circadian rhythm disturbance affecting sleep timing, duration, and rigidity as the core biological feature. It also links sleep disturbance with altered sleep architecture, emotion regulation, and, in aging and neurodegenerative contexts, reduced glymphatic clearance of brain protein waste.
The literature grounding associates sleep disturbance with aging, stress, anxiety, depression, and broader mental health problems. It also notes that stressful situations such as confinement, workplace disruption, and COVID-19-related illness or fear can worsen sleep problems.
The supplied reviews mention cognitive behavioural therapy for insomnia as a treatment approach and discuss practical adaptations of CBT-I elements for disrupted schedules and stress-related sleep problems. Beyond this, the grounding does not support a broader standard-of-care summary at the modality or drug-class level.
AI-generated summary grounded in MeSH and 6 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.