Diabetes Mellitus, Experimental
Recent clinical, regulatory, research and industry developments relating to this disease.
Streptozotocin-Induced Diabetic Models in Mice and Rats.
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.
The use of animal models in diabetes research.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 6 clinical trials expected to report results, the earliest in Q1 2027.
- Q1 2027A Randomized, Double-Masked, Multi-Center, 3-Arm Pivotal Phase 2/3 Study to Evaluate The Efficacy and Safety of Intravitreal EYE103 Compared With Intravitreal Ranibizumab (0.5mg) in Participants With Diabetic Macular Edema
- Q3 2027A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes
- Q3 2027Diabetes Diagnosis, Management, Prevention and Education in Guinea-Bissau
- Q3 2027Semaglutide for Dialysis-Treated Patients - a Glucose Time in Range Study- DIALYSIS-TIR Study
- Q4 2027Beta Cell Function in Type 2 Diabetes in Black Patients: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists
Clinical MilestonesView all 13Hide
- 2026-06-26A Randomized, Double-Masked, Multi-Center, 3-Arm Pivotal Phase 2/3 Study to Evaluate The Efficacy and Safety of Intravitreal EYE103 Compared With Intravitreal Ranibizumab (0.5mg) in Participants With Diabetic Macular EdemaResults expected Q1 2027
- 2026-04-20A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 DiabetesResults expected Q3 2027
- 2026-03-18A 96-week, Single-arm Study to Evaluate the Efficacy and Safety of 8mg Aflibercept in Subjects With Proliferative Diabetic Retinopathy (PDR) Without Center-involved Diabetic Macular Edema (DME)Results expected Q1 2028
- 2026-02-17Diabetes Diagnosis, Management, Prevention and Education in Guinea-BissauResults expected Q3 2027
- 2026-01-13Semaglutide for Dialysis-Treated Patients - a Glucose Time in Range Study- DIALYSIS-TIR StudyResults expected Q3 2027
- 2029-02-28Evaluate the Efficacy and Safety of the Combined Use of a Sodium-glucose Cotransporter 2 (iSGLT2) Inhibitor and a Dipeptidyl Peptidase-4 (iDPP -4) Inhibitor in the Treatment of Type 2 Diabetes Mellitus in Patients Treated With MetforminWithdrawn
- 2028-07-31Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes-----renal SubstudyWithdrawn
- 2028-03-01A Phase 3, Prospective, Adaptive, Randomized, Double-blind, Triple-masked, Parallel, Multicenter Clinical Trial to Evaluate the Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral NeuropathyWithdrawn
- 2028-02-01Phase III, Adaptive, Multicenter, Randomized, Superiority, Double-Dummy, Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of a Fixed-Dose Combination of a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor and a Thiazolidinedione in the Treatment of Type 2 Diabetes Mellitus, Compared to Monotherapy, in Patients Treated With MetforminWithdrawn
- 2027-01-01Comparison of Subvisible Retinal Laser Therapy With Intravitreal Bevacizumab in Treatment of Diabetic Macular EdemaWithdrawn
- 2029-02-28ClinicalEvaluate the Efficacy and Safety of the Combined Use of a Sodium-glucose Cotransporter 2 (iSGLT2) Inhibitor and a Dipeptidyl Peptidase-4 (iDPP -4) Inhibitor in the Treatment of Type 2 Diabetes Mellitus in Patients Treated With MetforminWithdrawn
- 2028-07-31ClinicalIntervention for High-normal Blood Pressure in Adults With Type 2 Diabetes-----renal SubstudyWithdrawn
- 2028-03-01ClinicalA Phase 3, Prospective, Adaptive, Randomized, Double-blind, Triple-masked, Parallel, Multicenter Clinical Trial to Evaluate the Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral NeuropathyWithdrawn
- 2028-02-01ClinicalPhase III, Adaptive, Multicenter, Randomized, Superiority, Double-Dummy, Double-Blind Clinical Trial to Evaluate the Efficacy and Safety of a Fixed-Dose Combination of a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor and a Thiazolidinedione in the Treatment of Type 2 Diabetes Mellitus, Compared to Monotherapy, in Patients Treated With MetforminWithdrawn
- 2027-01-01ClinicalComparison of Subvisible Retinal Laser Therapy With Intravitreal Bevacizumab in Treatment of Diabetic Macular EdemaWithdrawn
- 2026-06-30ClinicalMetformin Versus Standard of Care Treatment in Pregnant Women With Prediabetes: A Randomized TrialWithdrawn
- 2026-06-26ClinicalA Randomized, Double-Masked, Multi-Center, 3-Arm Pivotal Phase 2/3 Study to Evaluate The Efficacy and Safety of Intravitreal EYE103 Compared With Intravitreal Ranibizumab (0.5mg) in Participants With Diabetic Macular EdemaResults expected Q1 2027
- 2026-04-20ClinicalA Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 DiabetesResults expected Q3 2027
- 2026-03-18ClinicalA 96-week, Single-arm Study to Evaluate the Efficacy and Safety of 8mg Aflibercept in Subjects With Proliferative Diabetic Retinopathy (PDR) Without Center-involved Diabetic Macular Edema (DME)Results expected Q1 2028
- 2026-02-17ClinicalDiabetes Diagnosis, Management, Prevention and Education in Guinea-BissauResults expected Q3 2027
Research-associated treatments
Drugs and agents co-studied with this disease across the research literature — associative, not necessarily established treatments. Number shows shared papers.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Diabetes Mellitus, Experimental7
- Diabetes Mellitus, Type 24
- Benzhydryl Compounds2
- Cognitive Dysfunction2
- Diabetic Cardiomyopathies2
- Glucosides2
- Alzheimer Disease1
- Colorectal Neoplasms1
Leading journals6
- Alzheimer's research & therapy1
- BMC cancer1
- British journal of pharmacology1
- Cardiovascular diabetology1
- Current protocols1
- Diabetes1
Leading researchers8
- Wang X3
- Wang D2
- Xu Y2
- Yang M2
- Zhang H2
- Zhang W2
- Advani A1
- Al-Sharea A1
Affiliations (unnormalised)6
- School of Pharmacy2
- Asadabad School of Medical Sciences1
- Baker Heart & Diabetes Institute1
- BGI Institute of Applied Agriculture1
- Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou1
- Center for Innovation in Brain Science and Department of Pharmacology1
Disease biology
Key proteins & gene products studied in this disease. Number shows shared papers.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Experimental diabetes mellitus is an induced form of diabetes created in research settings by administering diabetogenic agents or by surgically removing the pancreas. It is used as an animal or laboratory model to study diabetes-related metabolism, drug therapy, genetics, and complications. The grounding describes it as a model rather than a naturally occurring disease entity.
It is caused experimentally by exposure to diabetogenic agents or by pancreatectomy. The supplied grounding specifically mentions streptozocin as a co-studied diabetogenic agent. No natural aetiology is supported by the grounding.
The model produces diabetes through loss of insulin production, either by chemical ablation of pancreatic beta cells or by removal of the pancreas. The resulting state is characterized by relative or absolute insulin deficiency and hyperglycaemia. The literature also links the model to studies of energy metabolism and the gastrointestinal microbiome.
As an experimentally induced condition, the main risk factor is exposure to diabetogenic agents or undergoing pancreatectomy in a research context. The grounding does not support additional patient-level risk factors. It is primarily a model-dependent outcome rather than a spontaneously arising disease.
The grounding does not support a clinical standard of care for this experimental model. In the literature, it is used to evaluate diabetes drug therapy and related mechanisms, including insulin and glucagon-like peptide-1 receptor biology. Treatment details beyond research use are not provided.
AI-generated summary grounded in MeSH and 1 peer-reviewed source. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.