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Disease

Dyspnea

Late-stage therapeutic developmentEmerging research
MeSHDyspnea
4
Publications
15
Clinical trials
2
Related conditions
2021
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q2 2028.
Upcoming Milestones
Major developments
Major trial resultsHigh impact
A Randomized Controlled Trial of Dexamethasone for Dyspnea in Cancer Patients
Results posted2026-06-11
Upcoming trial readoutImportant
Effect of PDE5 Inhibitor on Respiratory Symptoms in COPD Complicated by Pulmonary Hypertension
Results expected Q1 20292026-05-15
Clinical Milestones3View
Results posted 1
Results expected 2
Activity timeline3

Clinical trials

14 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
15
All trials
3
Active
8
Late-stage
6
Completed
Late-stage studies

Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease

Phase 4 · Completed · University of Aarhus

Ranolazine in Ischemic Cardiomyopathy Patients With Persistent Chest Pain or Dyspnea Despite Conventional Therapy: A Cross-Over Study

Phase 4 · Completed · Midwest Cardiovascular Research Foundation

Non Opioid Treatment for Experimental Dyspnea

Phase 3 · Completed · Assistance Publique - Hôpitaux de Paris

The Impact of Udenafil on Exercise Capacity in Severe COPD Patients

Phase 3 · Completed · Seoul National University Hospital

Mechanisms for Dyspnea on Exertion in Children With Obesity and Asthma: Distinct Physiological Phenotypes

Phase 4 · Withdrawn · Ohio State University

Effectiveness of Inhaled Corticosteroids in Preschool Children Following Hospital Admission for Acute Dyspnea and Wheeze

Phase 4 · Terminated · Princess Amalia Children's Clinic
Recruiting

Effect of PDE5 Inhibitor on Respiratory Symptoms in COPD Complicated by Pulmonary Hypertension

Phase 2 · Recruiting · VA Office of Research and Development

129Xe Gas Exchange MRI to Visualize Cardiopulmonary Function

Phase 2 · Recruiting · Bastiaan Driehuys
Recently completed

Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease

Phase 4 · Completed · University of Aarhus

Aerosol Inhalation Treatment for Dyspnea

Phase 1/2 · Completed · Beth Israel Deaconess Medical Center

Ranolazine in Ischemic Cardiomyopathy Patients With Persistent Chest Pain or Dyspnea Despite Conventional Therapy: A Cross-Over Study

Phase 4 · Completed · Midwest Cardiovascular Research Foundation

Effects of Prophylactic Subcutaneous Fentanyl on Exercise-Induced Breakthrough Dyspnea in Cancer Patients: A Preliminary Double-Blind, Randomized Controlled Trial

Phase 1/2 · Completed · M.D. Anderson Cancer Center

Non Opioid Treatment for Experimental Dyspnea

Phase 3 · Completed · Assistance Publique - Hôpitaux de Paris

The Impact of Udenafil on Exercise Capacity in Severe COPD Patients

Phase 3 · Completed · Seoul National University Hospital

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20032021
Major themes3
  • Disease Outbreaks1
  • Hospitalization1
  • Survivors1
Leading journals4
  • JAMA1
  • PLoS medicine1
  • Scientific reports1
  • The New England journal of medicine1
Leading researchers8
  • Adachi D1
  • Ayers M1
  • Baudry E1
  • Becquemont L1
  • Bellin MF1
  • Beurnier A1
  • Brunham RC1
  • Chan AK1
Affiliations (unnormalised)6
  • Center for Infectious Medicine1
  • Center for Neuroregeneration1
  • Emory University School of Medicine1
  • Harvard T.H. Chan School of Public Health1
  • Instituto Nacional de Cancerología1
  • National Autonomous University of Mexico1

Related conditions

2 matches

Diseases frequently studied alongside this one. Number shows shared papers.

COVID-193Fatigue3

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Difficult or labored breathing.

Identifiers
MeSHDyspnea
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.