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Disease

Empyema, Pleural

Late-stage therapeutic developmentEmerging research
MeSHEmpyema, Pleural
1
Publications
8
Clinical trials
12
Associated genes
1
Related proteins
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections.

Research2023-11-01Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q3 2028.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema (ONLY ONCE)
Results expected Q3 20282026-05-19
Clinical milestoneWorth watching
Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema
Completed2026-06-01
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

6 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
8
All trials
1
Active
3
Late-stage
5
Completed
Recruiting

Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema (ONLY ONCE)

Phase 4 · Recruiting · University of North Carolina, Chapel Hill
Recently completed

Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema

N/A · Completed · Fayoum University

IrRigation of the INfected Pleural Space With antiSEptic Solution (RINSE) - a Proof of Concept Study

Phase 2 · Completed · Alexandria University

Management of Pleural Space Infections

Phase 4 · Completed · Swedish Medical Center

Early Intervention for Complicated Parapneumonic Effusion: Randomized Controlled Trial for Fibrinolytic Therapy Versus VATs Decortication

N/A · Completed · Denver Health and Hospital Authority

A Prospective, Randomized, Double Blind, Controlled Trial to Evaluate Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Pleural Empyema

Phase 4 · Completed · Hospital Universitari Vall d'Hebron Research Institute

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023 · 29 cites
Recent publications

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023 · 29 cites
Major themes4
  • Bacteremia1
  • Brain Abscess1
  • Communicable Diseases1
  • Empyema, Pleural1
Leading journals1
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America1
Leading researchers8
  • Bø B1
  • Breistein R1
  • Dyrhovden R1
  • Eagan TM1
  • Fardal H1
  • Fløtten Ø1
  • Grøvan F1
  • Hjetland R1
Affiliations (unnormalised)6
  • Akershus University Hospital1
  • Department of Clinical Science1
  • Division of Medicine and Laboratory Sciences1
  • Førde Central Hospital1
  • Haraldsplass Deaconess Hospital1
  • Haukeland University Hospital1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

IGFBPL10.34SLC5A80.31CNTLN0.30FOCAD0.29SPAG160.29CNN30.28UCMA0.28ABLIM10.27KIAA13280.26ACO10.25ECT2L0.25SPAG10.24

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Cocaine- and amphetamine-regulated transcript proteinvia CARTPT0.20

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Suppurative inflammation of the pleural space.

Identifiers
MeSHEmpyema, Pleural
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.