Escherichia coli Infections
Recent clinical, regulatory, research and industry developments relating to this disease.
Trends in indigenous foodborne disease and deaths, England and Wales: 1992 to 2000.
Typical and atypical enteropathogenic Escherichia coli.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Cephalosporin Resistance1
- Chitosan1
- Disease Vectors1
- Escherichia coli Infections1
- Gastrointestinal Microbiome1
- Inflammatory Bowel Diseases1
- Methicillin-Resistant Staphylococcus aureus1
- Oxidative Stress1
Leading journals6
- Emerging infectious diseases1
- Gut1
- International journal of environmental research and public health1
- Nature communications1
- PLoS medicine1
- PloS one1
Leading researchers8
- Adak GK1
- Chen L1
- Chen Q1
- Davey PG1
- de Kraker ME1
- Dodiya HB1
- Dong Z1
- Estes JD1
Affiliations (unnormalised)6
- Centre for Infectious Disease Control1
- Graduate School of Life and Environmental Sciences1
- Institute of Functional Nano & Soft Materials (FUNSOM)1
- Instituto Butantan1
- PHLS Communicable Disease Surveillance Centre1
- Rush University Medical Center1
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Escherichia coli infections are infections caused by bacteria of the species Escherichia coli. The supplied literature highlights that some E. coli pathotypes, including enteropathogenic strains, are important causes of diarrheal disease and can also be associated with animal and human reservoirs.
The cause is infection with Escherichia coli bacteria. For typical enteropathogenic E. coli, humans are the only reservoir, while atypical enteropathogenic E. coli can have both animal and human reservoirs.
The grounding indicates that disease biology varies by E. coli pathotype, with typical and atypical enteropathogenic strains differing in genetic characteristics, serotypes, and virulence properties. Atypical enteropathogenic E. coli is described as being more closely related to Shiga toxin-producing E. coli, suggesting overlap in pathogenic features.
Exposure to human reservoirs is relevant for typical enteropathogenic E. coli, while exposure to both animal and human reservoirs is relevant for atypical enteropathogenic E. coli. The literature also indicates that typical EPEC is a leading cause of infantile diarrhea in developing countries, and atypical EPEC is more important in industrialized countries.
AI-generated summary grounded in MeSH and 2 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Infections with bacteria of the species ESCHERICHIA COLI.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.