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Disease

Gastroparesis

Late-stage therapeutic developmentEmerging research
MeSHGastroparesis
3
Publications
17
Clinical trials
1
Related conditions
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Treatment Protocol for the Compassionate Use of Domperidone
Results expected Q4 20272026-04-13
Upcoming trial readoutImportant
Low-dose Growth Hormone for the Treatment of Gastroparesis
Results expected Q4 20272026-04-16
Clinical Milestones5View
Results expected 3
Recently completed 2
Activity timeline5

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
17
All trials
5
Active
12
Late-stage
6
Completed
Late-stage studies

A Multicenter, Open Label, 3-Month Safety Study with Tradipitant in Patients with Idiopathic or Diabetic Gastroparesis

Phase 3 · Recruiting · Vanda Pharmaceuticals

Treatment Protocol for the Compassionate Use of Domperidone

Phase 3 · Recruiting · M.D. Anderson Cancer Center

Dynamic Positron Emission Tomography Imaging With 11C-ER176 to Delineate Macrophage Activation in Diabetic Gastroparesis

Phase 2/3 · Completed · Mayo Clinic

Sancuso® in Patients With Nausea and/or Vomiting From Gastroparesis: An Open Label Study.

Phase 3 · Completed · Temple University

VP-VLY-686-3301: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase Iii Study To Assess The Efficacy Of Tradipitant In Relieving Symptoms Of Gastroparesis

Phase 3 · Completed · Vanda Pharmaceuticals

Phase 3 Companion Study of Intranasal Metoclopramide in Men With Symptomatic Diabetic Gastroparesis

Phase 3 · Completed · Evoke Pharma
Recently completed

VP-VLY-686-3301: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase Iii Study To Assess The Efficacy Of Tradipitant In Relieving Symptoms Of Gastroparesis

Phase 3 · Completed · Vanda Pharmaceuticals

Dynamic Positron Emission Tomography Imaging With 11C-ER176 to Delineate Macrophage Activation in Diabetic Gastroparesis

Phase 2/3 · Completed · Mayo Clinic

Sancuso® in Patients With Nausea and/or Vomiting From Gastroparesis: An Open Label Study.

Phase 3 · Completed · Temple University

Prucalopride Versus Placebo in Gastroparesis: Randomized Placebo-controlled Crossover Trial

Phase 2/3 · Completed · University of Calgary

Phase 3 Companion Study of Intranasal Metoclopramide in Men With Symptomatic Diabetic Gastroparesis

Phase 3 · Completed · Evoke Pharma

Nortriptyline for Idiopathic Gastroparesis: A Multicenter, Randomized, Double-Masked, Placebo-Controlled Trial (NORIG)

Phase 3 · Completed · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes5
  • Diabetes Mellitus, Type 22
  • Gastric Emptying2
  • Glucagon-Like Peptide-1 Receptor Agonists2
  • Gastroparesis1
  • Hypoglycemic Agents1
Leading journals3
  • Gastrointestinal endoscopy1
  • The Journal of clinical endocrinology and metabolism1
  • The Medical journal of Australia1
Leading researchers8
  • Addissie BD1
  • Brown C1
  • Confer BD1
  • Diehl DL1
  • Dove JT1
  • Greenfield JR1
  • Horowitz M1
  • Jalleh RJ1
Affiliations (unnormalised)6
  • Adelaide Medical School1
  • Center for Obesity and Metabolic Research1
  • Flinders Medical Centre1
  • Garvan Institute of Medical Research1
  • Geisinger Commonwealth School of Medicine1
  • Geisinger Medical Center1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Diabetes Mellitus, Type 23

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Chronic delayed gastric emptying. Gastroparesis may be caused by motor dysfunction or paralysis of STOMACH muscles or may be associated with other systemic diseases such as DIABETES MELLITUS.

Identifiers
MeSHGastroparesis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.