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Disease

Hypoglycemia

Late-stage therapeutic developmentEmerging researchRising momentum
8
Publications
18
Clinical trials
2
Related conditions
2
Related treatments
1
Related proteins
2024
Latest publication
Current focus
P43220 biologyTherapeutic developmentMetabolic & lifestyle factors
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

GLP-1 Receptor Agonist Exposures Are Increasingly Common and Generally Associated with Mild Symptoms: A Single Poison Center Experience.

Research2024-06-11Journal of medical toxicology : official journal of the American College of Medical Toxicology

From liver to hormones: The endocrine consequences of cirrhosis.

Research2024-03-01World journal of gastroenterology

The physiology of glucagon-like peptide 1.

Research2007-10-01Physiological reviews

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Research-associated treatments

Drugs and agents co-studied with this disease across the research literature — associative, not necessarily established treatments. Number shows shared papers.

Clinical trials

16 sponsors · 0 new · 1 completed in the last 12 months (net -1)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
14
Late-stage
6
Completed
Late-stage studies
Recently completed

Research activity

8 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20022024
Most influential
Recent publications
Major themes8
  • Hypoglycemia4
  • Diabetes Mellitus, Type 22
  • Diabetes Mellitus1
  • Glucagon-Like Peptide-1 Receptor Agonists1
  • Glycemic Index1
  • Hypoglycemic Agents1
  • Insulins1
  • Islets of Langerhans1
Leading journals6
  • Diabetologia2
  • Diabetes, obesity & metabolism1
  • Journal of diabetes research1
  • Journal of medical toxicology : official journal of the American College of Medical Toxicology1
  • Physiological reviews1
  • The Journal of clinical endocrinology and metabolism1
Leading researchers8
  • Holst JJ2
  • Acreman S1
  • Asterholm IW1
  • Atti S1
  • Avgerinos I1
  • Basco D1
  • Behle K1
  • Bekiari E1
Affiliations (unnormalised)6
  • Oxford Centre for Diabetes2
  • Aarhus University Hospital1
  • Alabama Poison Information Center1
  • Biomedical Research Centre1
  • Center for Integrative Genomics1
  • Clinical Research and Evidence-Based Medicine Unit1

Disease biology

1 match

Key proteins & gene products studied in this disease. Number shows shared papers.

Related conditions

2 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Disease profile

A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.

Overview

Hypoglycemia is a syndrome characterized by abnormally low blood glucose. It can arise from diverse etiologies and, when severe, can deprive the central nervous system of glucose, leading to symptoms such as hunger, sweating, paresthesia, impaired mental function, seizures, coma, and death.

Causes

Clinical hypoglycemia has diverse etiologies. The supplied grounding specifically links hypoglycemia to chemically induced contexts and to endocrine disturbance in liver cirrhosis, but does not provide a more detailed causal list.

Pathophysiology

The core mechanism is insufficient blood glucose availability, with severe episodes causing glucose deprivation of the central nervous system. The grounding also supports a metabolic context in which hypoglycemia is considered alongside glycemic indices and oxidative stress, and it notes GLP-1 biology as relevant to glucose regulation, but it does not establish a specific hypoglycemia mechanism beyond low glucose itself.

Risk factors

The grounding supports liver cirrhosis as a condition associated with hypoglycemia. It also indicates chemically induced hypoglycemia and broader diabetes-related glycemic dysregulation as relevant contexts, but does not specify additional risk factors.

Current standard of care

The supplied material supports glucagon as a treatment modality and insulin as a co-studied drug in the hypoglycemia literature, but it does not provide a full treatment algorithm. At the modality level, management is therefore represented by glucose-raising therapy and glucagon-based rescue treatment, without further detail.

AI-generated summary grounded in MeSH and 4 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.

Identifiers
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.