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Drug

Glucagon

Approved · EMA
ClassGlucagon receptor agonistActively researchedLate-stage developmentRising momentum
Also known as Baqsimi, Gvoke, GlucaGen, Glucagone+1 more

Baqsimi, Gvoke, GlucaGen, Glucagone, Glucagonum.

25
Research papers
8
Active clinical trials
Glucagon receptor
Primary target
4
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Recall (Class II): GLUCAGON

Regulatory2026-06-23FDA

GLP-1 Receptor Agonists.

Research2026-04-01The New England journal of medicine

Human Models of Selective Insulin Resistance: Pancreatic Clamp

Clinical trial2026-02-06Results expected Q4 2028 · ClinicalTrials.gov

Approval: Ogluo (EMA)

Regulatory2021-02-11EMA

Approval: Baqsimi (EMA)

Regulatory2019-12-16EMA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Glucagon
Aliases & brands
BaqsimiGvokeGlucaGenGlucagoneGlucagonum
RxNorm CUI
4832
ChEMBL ID
CHEMBL5314341
ATC codes
H04AA01
UNII
76LA80IG2G
Primary mechanism
Glucagon receptor agonist
Regulatory jurisdictions
emafda

Pharmacology & targets

1 target

Known molecular targets and mechanisms supported by curated pharmacology databases.

Glucagon receptor
GCGR · P47871
AGONISTGlucagon receptor agonist

Regulatory timeline

4 events

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2019-12-16
Latest approval
2021-02-11
Authorities
FDA · EMA
Total events
4
fdaU.S. Food and Drug Administration· 2 events
2026-06-23RecallSafety
Recall (Not Yet Classified): GLUCAGON
Evidence ↗
2026-06-23RecallSafety
Recall (Class II): GLUCAGON
Evidence ↗
emaEuropean Medicines Agency· 2 events
2021-02-11Approval
Approval: Ogluo (EMA)

Indication: Ogluo is indicated for the treatment of severe hypoglycaemia in adults, adolescents, and children aged 2 years and over with diabetes mellitus.

Evidence ↗
2019-12-16Approval
Approval: Baqsimi (EMA)

Indication: Baqsimi is indicated for the treatment of severe hypoglycaemia in adults, adolescents, and children aged 4 years and over with diabetes mellitus.

Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

66 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
66
registered trials across all phases
LATEST COMPLETION 2025
8
Active studies
4
Recruiting
26
Late-stage (III+)
45
Completed
13
Discontinued
PHASE DISTRIBUTIONn = 66
Early Phase 12Phase 122Phase 1 / 22Phase 214Phase 2 / 31Phase 31Phase 49Phase N / A15

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Recent completions

Trials that read out recently, adding to the completed evidence base.

Research activity

25 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19932026
Most influential
Recent papers
Major research themes8
Diabetes Mellitus, Type 25Glucagon4Obesity3Glucagon-Like Peptide-1 Receptor Agonists2Incretins2Anti-Obesity Agents1Bariatric Surgery1Cardiovascular Diseases1
Journals, researchers & institutions
Top journals
  • The Journal of clinical investigation4
  • Diabetes2
  • Diabetologia2
  • Endocrinology2
  • International journal of molecular sciences2
  • The Journal of endocrinology2
Leading researchers
  • Holst JJ5
  • Drucker DJ4
  • Heimesaat MM2
  • Knop FK2
  • Knudsen JG2
  • Nauck MA2
  • Thorens B2
  • Acreman S1
Leading institutions
free-text, unnormalised
  • University of Copenhagen4
  • Center for Clinical Metabolic Research2
  • Center for Integrative Genomics2
  • Department of Clinical Medicine2
  • Steno Diabetes Center Copenhagen2
  • Allegheny General Hospital1

Related diseases

7 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Related drugs

8 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Studied across 21 of the same disease areas as Glucagon in the shared literature.

14 shared papers21 shared diseases

Studied across 13 of the same disease areas as Glucagon in the shared literature.

13 shared diseases1 shared paper

Studied across 9 of the same disease areas as Glucagon in the shared literature.

9 shared diseases2 shared papers

Studied across 8 of the same disease areas as Glucagon in the shared literature.

8 shared diseases1 shared paper

Studied across 5 of the same disease areas as Glucagon in the shared literature.

5 shared diseases2 shared papers

Studied across 5 of the same disease areas as Glucagon in the shared literature.

5 shared diseases1 shared paper

Studied across 2 of the same disease areas as Glucagon in the shared literature.

2 shared diseases1 shared paper

Studied across 2 of the same disease areas as Glucagon in the shared literature.

2 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.