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Drug

C-Peptide

In clinical development
Emerging researchEarly-to-mid developmentRising momentum

Also known as Insulin c-peptide, Proinsulin c-peptide.

RxNorm2629680ChEMBLCHEMBL4594409UNIIO2J76Y002M
3
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

On the Regulation of Hepatic Glucose Metabolism During Insulin-induced Hypoglycemia

Clinical trial2026-02-17Results expected Q2 2027 · ClinicalTrials.gov

A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass.

Research2023-10-17Frontiers in endocrinology

Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel.

Research2020-08-26Diabetes

A Double-Blind, Randomized, Placebo-Controlled, 2-Way Cross-Over Study to Evaluate the Effect of Single Dose Canagliflozin on Kinetics of C-Peptide in Healthy Subjects

Clinical trial2012-10-01Completed · ClinicalTrials.gov

Effect of C-Peptide on Diabetic Peripheral Neuropathy, a 6 Months Randomized Double-Blind, Placebo Controlled, Dose-Finding, Multicenter Study, With Parallel Groups

Clinical trial2004-12-01Completed · ClinicalTrials.gov

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

Research1993-01-01The Journal of clinical investigation

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
C-Peptide
Aliases & brands
Insulin c-peptideProinsulin c-peptide
RxNorm CUI
2629680
ChEMBL ID
CHEMBL4594409
UNII
O2J76Y002M

Clinical trials

3 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
3
registered trials across all phases
LATEST COMPLETION 2012
1
Active studies
1
Recruiting
2
Completed
PHASE DISTRIBUTIONn = 3
Early Phase 11Phase 11Phase 21

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
19932023
Major research themes3
Diabetes Mellitus, Type 21Gastric Bypass1Gastrointestinal Microbiome1
Journals, researchers & institutions
Top journals
  • Diabetes1
  • Frontiers in endocrinology1
  • The Journal of clinical investigation1
Leading researchers
  • Astiarraga B1
  • Buzzetti R1
  • Creutzfeldt W1
  • Ebert R1
  • Fernández-Veledo S1
  • Guerrero-Pérez F1
  • Heimesaat MM1
  • Hernández-Montoliu L1
Leading institutions
free-text, unnormalised
  • Abdominal Center1
  • Bellvitge University Hospital-Institut d'Investigació Biomédica de Bellvitge1
  • Blizard Institute1
  • Campus Bio-Medico University1
  • CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III (ISCIII)1
  • Clinical Nutrition Unit. Bellvitge University Hospital-Institut d'Investigació Biomédica de Bellvitge1

Related diseases

1 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas
Diabetes Mellitus, Type 23

Related drugs

2 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Insulin

Studied across 3 of the same disease areas as C-Peptide in the shared literature.

3 shared diseases1 shared paper
Glucagon

Studied across 2 of the same disease areas as C-Peptide in the shared literature.

2 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials