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Disease

Hypophosphatemia

Late-stage therapeutic developmentEmerging research
MeSHHypophosphatemia
1
Publications
11
Clinical trials
3
Associated genes
1
Related proteins
2008
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Chronic kidney disease mineral and bone disorder in children.

Research2007-11-28Pediatric nephrology (Berlin, Germany)

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q2 2027.
  • 1 industry development reported.
Upcoming Milestones
Clinical Milestones4View
Results expected 2
Recently completed 2
Industry & Market1View
Activity timeline5

Clinical trials

9 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
11
All trials
4
Active
7
Late-stage
6
Completed
Late-stage studies

Intravenous Iron-induced Hypophosphatemia in Patients With Roux-en-Y Gastric Bypass: a Single-blind, Randomized Clinical Trial Comparing Iron Isomaltoside (Monofer®) and Ferric Carboxymaltose (Ferinject®)

Phase 4 · Recruiting · Lucie Favre

The Efficacy and Safety of Diluted Oral Phosphate Enema Versus Intravenous Sodium Glycerophosphate in The Treatment of Hypophosphatemia in ICU Patients

Phase 2/3 · Completed · Ain Shams University

An Open-label, Multi-center, Single-cohort, Post-marketing Phase 4 Study to Evaluate the Efficacy, Pharmacodynamics, and Safety of the Anti-FGF23 Antibody, KRN23, in Pediatric Chinese Patients With X-linked Hypophosphatemic Rickets/Osteomalacia (XLH)

Phase 4 · Completed · Kyowa Kirin Co., Ltd.

An Investigator-sponsored Phase 3b Open-label Study of Anti- FGF23 Antibody Burosumab (KRN23) in Adult Patients With Xlinked Hypophosphatemia (XLH) in GERmany - BurGER

Phase 3 · Completed · Wuerzburg University Hospital

An Open Label Trial to Assess the Safety and Efficacy of Burosumab (KRN23), an Investigational Antibody to FGF23, in a Single Pediatric Patient With Epidermal Nevus Syndrome(ENS) and Associated Hypophosphatemic Rickets

Phase 3 · Completed · Redwood Dermatology Sciences

Examining the Effect of Burosumab on Muscle Function Using MR Spectroscopy

Phase 4 · Completed · Yale University
Recruiting

Intravenous Iron-induced Hypophosphatemia in Patients With Roux-en-Y Gastric Bypass: a Single-blind, Randomized Clinical Trial Comparing Iron Isomaltoside (Monofer®) and Ferric Carboxymaltose (Ferinject®)

Phase 4 · Recruiting · Lucie Favre

A Multicenter, Open-label, Phase 1/2, Dose-escalation and Subsequent Safety Extension Study of Subcutaneous KK8123 in Adult Patients With X-linked Hypophosphatemia

Phase 1/2 · Recruiting · Kyowa Kirin Co., Ltd.

Evaluation of Dipyridamole in Preventing Post-Transplant Hypophosphatemia in Kidney Transplant Recipients

Phase 2 · Recruiting · Stanford University

A Prospective Clinical Study Evaluating the Effectiveness and Safety of Enteral Supplementation With Sodium Dihydrogen Phosphate and Disodium Hydrogen Phosphate Granules for Varying Degrees of Hypophosphatemia

N/A · Recruiting · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Recently completed

The Efficacy and Safety of Diluted Oral Phosphate Enema Versus Intravenous Sodium Glycerophosphate in The Treatment of Hypophosphatemia in ICU Patients

Phase 2/3 · Completed · Ain Shams University

An Open-label, Multi-center, Single-cohort, Post-marketing Phase 4 Study to Evaluate the Efficacy, Pharmacodynamics, and Safety of the Anti-FGF23 Antibody, KRN23, in Pediatric Chinese Patients With X-linked Hypophosphatemic Rickets/Osteomalacia (XLH)

Phase 4 · Completed · Kyowa Kirin Co., Ltd.

An Investigator-sponsored Phase 3b Open-label Study of Anti- FGF23 Antibody Burosumab (KRN23) in Adult Patients With Xlinked Hypophosphatemia (XLH) in GERmany - BurGER

Phase 3 · Completed · Wuerzburg University Hospital

Examining the Effect of Burosumab on Muscle Function Using MR Spectroscopy

Phase 4 · Completed · Yale University

An Open Label Trial to Assess the Safety and Efficacy of Burosumab (KRN23), an Investigational Antibody to FGF23, in a Single Pediatric Patient With Epidermal Nevus Syndrome(ENS) and Associated Hypophosphatemic Rickets

Phase 3 · Completed · Redwood Dermatology Sciences

The Role of Parathyroid Hormone in the Pathogenesis of Skeletal Disease in X-linked Hypophosphatemic Rickets (XLH)

Phase 3 · Completed · Yale University

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Chronic kidney disease mineral and bone disorder in children.

Pediatric nephrology (Berlin, Germany) · 2008 · 47 cites
Recent publications

Chronic kidney disease mineral and bone disorder in children.

Pediatric nephrology (Berlin, Germany) · 2008 · 47 cites
Leading journals1
  • Pediatric nephrology (Berlin, Germany)1
Leading researchers3
  • Bakkaloglu S1
  • Salusky I1
  • Wesseling K1
Affiliations (unnormalised)1
  • David Geffen School of Medicine at UCLA1

Associated genes

3 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

FGF230.52PHEX0.26NHERF10.26

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Fibroblast growth factor 23via FGF230.52

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition of an abnormally low level of PHOSPHATES in the blood.

Identifiers
MeSHHypophosphatemia
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.