NHERF1

Gene

NHERF family PDZ scaffold protein 1

HGNCHGNC:11075 EnsemblENSG00000109062 NCBI Gene9368

Locus: gene with protein productLocation: 17q25.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSLC9A3R1 · NHERF · EBP50 · NHERF-1 · NHE-RF

View full nomenclature history (12)

Previous symbolsSLC9A3R1

Alias symbolsNHERF, EBP50, NHERF-1, NHE-RF

Previous namessolute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1, solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1, SLC9A3 regulator 1

Alias namesezrin-radixin-moesin-binding phosphoprotein 50, Na(+)/H(+) exchange regulatory cofactor 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Nephrolithiasis

Hypophosphatemia

Genetic Diseases, Inborn

Kidney Failure, Chronic

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PDZ domain containingMicroRNA protein coding host genesNHERF family PDZ scaffold proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.