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Disease

Nephrolithiasis

Late-stage therapeutic development
Also known as Stone - kidney/ureter, calculus of kidney and ureter, kidney stone, kidney stones+4 more

Stone - kidney/ureter, calculus of kidney and ureter, kidney stone, kidney stones, renal calculi, CAON, nephrolithiasis, calcium oxalate, urolithiasis, calcium oxalate.

17
Clinical trials
12
Associated genes
4
Related proteins
Current focus
1 biologyTherapeutic developmentWnt-5a biologyDisease mechanisms & pathology

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2029.
Upcoming Milestones
Clinical Milestones5View
Results expected 2
Recently completed 3
Activity timeline5

Clinical trials

15 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
17
All trials
6
Active
10
Late-stage
6
Completed
Late-stage studies

Prospective, Randomized Study on the Efficiency of Alpha-Blockers Prior to Ureteral Sheath Placement in Flexible Ureterolithotripsy

Phase 4 · Recruiting · Pedro de Figueiredo Buchalla

Randomized Placebo-controlled Trial to Assess Efficacies of EMPAgliflozin and Personalized Dietary Counselling for Kidney STONE Prevention in Patients With Calcium Kidney Stones Acronym: EMPASTONE Trial

Phase 3 · Recruiting · Insel Gruppe AG, University Hospital Bern

Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets

Phase 4 · Recruiting · Huashan Hospital

Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss

Phase 4 · Completed · University of Texas Southwestern Medical Center

Narcotic-Free Percutaneous Nephrolithotomy

Phase 4 · Completed · Icahn School of Medicine at Mount Sinai

Randomized Double-blind Placebo-controlled Trial Assessing the Efficacy of Standard and Low Dose Hydrochlorothiazide Treatment in the Prevention of Recurrent Nephrolithiasis

Phase 3 · Completed · Insel Gruppe AG, University Hospital Bern
Recruiting

Prospective, Randomized Study on the Efficiency of Alpha-Blockers Prior to Ureteral Sheath Placement in Flexible Ureterolithotripsy

Phase 4 · Recruiting · Pedro de Figueiredo Buchalla

Prediction of Recurrence and Complications of Nephrolithiasis Using a Precision Medicine Approach

N/A · Recruiting · Centre Hospitalier Universitaire, Amiens

Double-Blind Randomized Placebo Controlled Trial of Intravesical Bupivacaine on Post-Operative Ureteroscopy Pain

Phase 2 · Recruiting · University of Chicago

Randomized Placebo-controlled Trial to Assess Efficacies of EMPAgliflozin and Personalized Dietary Counselling for Kidney STONE Prevention in Patients With Calcium Kidney Stones Acronym: EMPASTONE Trial

Phase 3 · Recruiting · Insel Gruppe AG, University Hospital Bern

Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets

Phase 4 · Recruiting · Huashan Hospital
Recently completed

Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss

Phase 4 · Completed · University of Texas Southwestern Medical Center

Narcotic-Free Percutaneous Nephrolithotomy

Phase 4 · Completed · Icahn School of Medicine at Mount Sinai

Medication Facilitated Ureteral Access Sheath Deployment During Ureteroscopy and Endoscopic-Guided Percutaneous Nephrolithotomy: A Randomized Double-Blind Placebo Controlled Trial of Tadalafil, Tamsulosin and Combination

Phase 4 · Completed · University of California, Irvine

Pain Outcomes of Non-opioid Analgesia After Ureteroscopy or Percutaneous Nephrolithotomy for Nephrolithiasis: a Prospective Randomized Controlled Trial.

Phase 3 · Completed · Montefiore Medical Center

Randomized Double-blind Placebo-controlled Trial Assessing the Efficacy of Standard and Low Dose Hydrochlorothiazide Treatment in the Prevention of Recurrent Nephrolithiasis

Phase 3 · Completed · Insel Gruppe AG, University Hospital Bern

Cystone for Treatment of Nephrolithiasis

Phase 1/2 · Completed · Mayo Clinic

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

SLC26A10.60SLC34A10.57CYP24A10.55UMOD0.54CD440.52HAO10.52ALPL0.50CLDN140.50DGKH0.48TMEM1710.48WDR720.47TFAP2B0.47

Disease biology

4 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialvia CYP24A10.55Prostaglandin E2 receptor EP1 subtypevia PTGER10.42Protein Wnt-5avia WNT5A0.37Occludinvia OCLN0.21

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Formation of stones in the KIDNEY.

Synonyms

Stone - kidney/ureter, calculus of kidney and ureter, kidney stone, kidney stones, renal calculi, CAON, nephrolithiasis, calcium oxalate, urolithiasis, calcium oxalate

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.