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ALPL

Gene

alkaline phosphatase, biomineralization associated

HGNCHGNC:438EnsemblENSG00000162551NCBI Gene249
Locus: gene with protein productLocation: 1p36.12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHOPS · TNSALP · TNALP · TNAP
View full nomenclature history (6)
Previous symbolsHOPS
Alias symbolsTNSALP, TNALP, TNAP
Previous namesalkaline phosphatase, liver/bone/kidney
Alias namestissue non-specific alkaline phosphatase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Osteogenesis Imperfecta
Genetic Diseases, Inborn
Nephrolithiasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Alkaline phosphatases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.