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Disease

Intervertebral Disc Degeneration

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHIntervertebral Disc Degeneration
3
Publications
6
Clinical trials
12
Associated genes
1
Related proteins
2025
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

5 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
6
All trials
2
Active
1
Late-stage
4
Completed
Late-stage studies

Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery

Phase 4 · Completed · Serviço de Anestesiologia de Joinville
Recently completed

Autologous Mesenchymal Stem/Stromal Cells for the Treatment of Workers Affected by Chronic Low Back Pain Due to Multilevel InterVErtebral Disc Degeneration: a Phase IIB Randomized Clinical Trial

Phase 2 · Completed · Fondazione Policlinico Universitario Campus Bio-Medico

NuTech NuCel®: A Prospective, Efficacy Study of NuCel® in Patients Undergoing Fusion for One, Two or Three Level Degenerative Disease of the Lumbar Spine.

N/A · Completed · NuTech Medical, Inc

A Prospective Randomized Multicentre Phase I/II Clinical Trial to Evaluate Safety and Efficacy of NOVOCART® Disc Plus Autologous Disc Chondrocyte Transplantation (ADCT) in the Treatment of Nucleotomized and Degenerative Lumbar Discs to Avoid Secondary Disease

Phase 1/2 · Completed · Tetec AG

Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery

Phase 4 · Completed · Serviço de Anestesiologia de Joinville

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20162025
Major themes4
  • Intervertebral Disc Degeneration2
  • Cellular Microenvironment1
  • Intervertebral Disc1
  • Neuralgia1
Leading journals3
  • ACS nano1
  • Frontiers in immunology1
  • Neurosurgery1
Leading researchers8
  • Amirdelfan K1
  • Benyamin R1
  • Bundschu R1
  • Burgher AH1
  • Chen L1
  • Chen X1
  • Doust MW1
  • Feng S1
Affiliations (unnormalised)6
  • *Center for Clinical Research and Carolina's Pain Institute1
  • First Affiliated Hospital of Shihezi University1
  • Honghui Hospital1
  • Qilu Hospital of Shandong University1
  • The Second Hospital of Shandong University1
  • Tianjin Medical University General Hospital1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

COL11A10.51COL9A20.48COL9A30.46CILP0.38ASPN0.38THBS20.38MMP90.38CD163L10.25P4HA10.24FER1L50.15ERVFRD-10.11CILP20.06

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Matrix metalloproteinase-9via MMP90.38

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.

Identifiers
MeSHIntervertebral Disc Degeneration
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.