P4HA1

Gene

prolyl 4-hydroxylase subunit alpha 1

HGNCHGNC:8546 EnsemblENSG00000122884 NCBI Gene5033

Locus: gene with protein productLocation: 10q22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asP4HA · C-P4Halpha(I)

View full nomenclature history (5)

Previous symbolsP4HA

Alias symbolsC-P4Halpha(I)

Previous namesprocollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I, prolyl 4-hydroxylase, alpha polypeptide I

Alias namescollagen prolyl 4-hydroxylase alpha(I)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Dengue

Parkinson's Disease

Intervertebral Disc Degeneration

Neoplasms

Central Nervous System Neoplasms

Glioma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Iron (II) and 2-oxoglutarate dependent oxygenasesProlyl 4-hydroxylase subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.