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Disease

Intracranial Aneurysm

Late-stage therapeutic developmentEmerging research
MeSHIntracranial Aneurysm
1
Publications
13
Clinical trials
12
Associated genes
2
Related proteins
2024
Latest publication
Current focus
Therapeutic developmentGenetics & risk factorsDisease mechanisms & pathology
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones3View
Results expected 1
Recently completed 2
Activity timeline3

Clinical trials

8 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
13
All trials
2
Active
4
Late-stage
6
Completed
Late-stage studies

Prospective, Post-registration, Interventional, Randomized, in Parallel Groups, Multicenter Eurasian Clinical Study of DERIVO®/DERIVO® Mini Aneurysm Embolization Device, Europe-Asia

Phase 4 · Recruiting · Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health

Prophylactic Administration of Tirofiban for Preventing Thromboembolic Events in Stent-assisted Coiling and Flow Diversion Treatments of Unruptured Intracranial Aneurysms

Phase 2/3 · Completed · Beijing Tiantan Hospital

A Study of Platelet Function Test in the Application of Prevention of Ischemic Events After Stent Placement in Intracranial Aneurysms

Phase 4 · Completed · Beijing Neurosurgical Institute

Seizure Prophylaxis in Aneurysm Repair

Phase 4 · Completed · University of Michigan
Recruiting

Prospective, Post-registration, Interventional, Randomized, in Parallel Groups, Multicenter Eurasian Clinical Study of DERIVO®/DERIVO® Mini Aneurysm Embolization Device, Europe-Asia

Phase 4 · Recruiting · Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health

Indobufen Versus Aspirin in Endovascular Unruptured Intracranial Aneurysms Treatment

N/A · Recruiting · Beijing Tiantan Hospital
Recently completed

Prophylactic Administration of Tirofiban for Preventing Thromboembolic Events in Stent-assisted Coiling and Flow Diversion Treatments of Unruptured Intracranial Aneurysms

Phase 2/3 · Completed · Beijing Tiantan Hospital

Population-based Investigation of Aneurysm Incidence

N/A · Completed · Beijing Tiantan Hospital

Seizure Prophylaxis in Aneurysm Repair

Phase 4 · Completed · University of Michigan

Guided Versus Standard Antiplatelet Therapy in Intracranial Aneurysm Intervention With Stents: a Cluster Randomized Controlled Cohort Study

N/A · Completed · Beijing Tiantan Hospital

A Study of Platelet Function Test in the Application of Prevention of Ischemic Events After Stent Placement in Intracranial Aneurysms

Phase 4 · Completed · Beijing Neurosurgical Institute

Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients

N/A · Completed · NYU Langone Health

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics.

Brain : a journal of neurology · 2024 · 13 cites
Recent publications

Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics.

Brain : a journal of neurology · 2024 · 13 cites
Major themes3
  • Genome-Wide Association Study1
  • Intracranial Aneurysm1
  • Proteome1
Leading journals1
  • Brain : a journal of neurology1
Leading researchers8
  • Huang Q1
  • Jiang A1
  • Li Q1
  • Lin R1
  • Liu H1
  • Liu J1
  • Lv N1
  • Wang C1
Affiliations (unnormalised)2
  • Changhai Hospital1
  • Neurovascular Center1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

STARD130.43CTAGE10.40ANGPTL60.37MELTF0.34CD163L10.34TENM30.32TENM20.32OLFML2A0.32SOX170.32SLC47A10.31SCARF10.31PRDM20.31

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Proliferation marker protein Ki-67via MKI670.29NAD-dependent protein deacetylase sirtuin-3, mitochondrialvia SIRT30.14

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)

Identifiers
MeSHIntracranial Aneurysm
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.