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Disease

Malaria, Cerebral

Late-stage therapeutic developmentEmerging research
MeSHMalaria, Cerebral
1
Publications
5
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
DON in Pediatric Cerebral Malaria: A Phase I/IIa Dose-Escalation Safety Study
Results expected Q4 20262026-06-29
Clinical Milestones1View
Results expected 1
Activity timeline1

Clinical trials

4 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
5
All trials
1
Active
1
Late-stage
4
Completed
Late-stage studies

Treating Brain Swelling in Pediatric Cerebral Malaria

Phase 3 · Completed · Michigan State University
Recruiting

DON in Pediatric Cerebral Malaria: A Phase I/IIa Dose-Escalation Safety Study

Phase 1/2 · Recruiting · Douglas Postels, MD, MS
Recently completed

Treating Brain Swelling in Pediatric Cerebral Malaria

Phase 3 · Completed · Michigan State University

Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide (iNO) as Adjunctive Treatment for Cerebral Malaria in Children: A Randomized Open Label Phase II Clinical Trial

Phase 2 · Completed · Epicentre

A Phase 1 Double-Blind, Placebo-Controlled, Randomized Multiple Dose Escalation Study to Evaluate the Safety, Tolerance, and Pharmacokinetics/Pharmacodynamics of a New GMP Formulation of Intravenous Artesunate if Healthy Subjects

Phase 1 · Completed · U.S. Army Medical Research and Development Command

A Phase 1 Randomized, Double-Blind, Placebo-Controlled Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Single Intravenous Doses of Artesunate Administered to Healthy Subjects

Phase 1 · Completed · U.S. Army Medical Research and Development Command

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes2
  • Illness Behavior1
  • Malaria, Cerebral1
Leading journals1
  • Journal of neuroinflammation1
Leading researchers8
  • Aditi1
  • Avchalumov Y1
  • Baumgartner TJ1
  • Cisneros I1
  • Di Re J1
  • Dineley KT1
  • Domingo ND1
  • Dvorak NM1
Affiliations (unnormalised)5
  • Center for Addiction Sciences and Therapeutics1
  • Center for Immunity and Inflammation and Department of Pharmacology1
  • Clinical Sciences Program1
  • University of Texas1
  • University of Texas Medical Branch1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)

Identifiers
MeSHMalaria, Cerebral
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.