KIR2DL3

Gene

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3

HGNCHGNC:6331 EnsemblENSG00000243772 NCBI Gene3804

Locus: gene with protein productLocation: 19q13.42

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Killer cell immunoglobulin-like receptor 2DL3P43628

Protein · therapeutic target

Clinical-stage target · 2 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known ascl-6 · nkat2 · nkat2a · nkat2b · p58 · CD158B2

View full nomenclature history (7)

Alias symbolscl-6, nkat2, nkat2a, nkat2b, p58, CD158B2

Previous nameskiller cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Myeloid, Acute

Familial prostate cancer

Prostatic Neoplasms

Multiple Myeloma

Leukemia, Lymphocytic, Chronic, B-Cell

Myelodysplastic syndrome

Squamous Cell Carcinoma of Head and Neck

Malaria, Cerebral

Lupus Erythematosus, Systemic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesKiller cell immunoglobulin like receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.