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Disease
Meniere's Disease
Late-stage therapeutic developmentEmerging research
1
Publications
12
Clinical trials
2024
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Research2024-02-23Genes and immunity
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 3 clinical trials with recent milestones (1 completed or reporting results).
Major developments
Major trial resultsHigh impact
Results posted2026-06-26
Major clinical milestoneImportant
Primary completion2026-05-01
Clinical MilestonesViewHide
Results posted
Recently completed
- 2026-05-01A Multicenter, Double-blinded, Randomized, Placebo-controlled Trial to Compare the Effectiveness of Intratympanic Injections methylPREDnisolon Versus Placebo in the Treatment of Vertigo Attacks in MENière's Disease (PREDMEN Trial).Primary completion
- 2025-09-03Repurposed Use of Allergic Rhinitis and Allergic Asthma Drug to Reduce Vertigo and Hearing Loss in Meniere's DiseasePrimary completion
Activity timeline3
- 2026-06-26ClinicalA Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of SPI-1005 in Meniere's Disease and Open Label Extension Study to Evaluate the Chronic Safety of SPI-1005Results posted
- 2026-05-01ClinicalA Multicenter, Double-blinded, Randomized, Placebo-controlled Trial to Compare the Effectiveness of Intratympanic Injections methylPREDnisolon Versus Placebo in the Treatment of Vertigo Attacks in MENière's Disease (PREDMEN Trial).Primary completion
- 2025-09-03ClinicalRepurposed Use of Allergic Rhinitis and Allergic Asthma Drug to Reduce Vertigo and Hearing Loss in Meniere's DiseasePrimary completion
Clinical trials
The current development programme across all trial phases.
Clinical programme
12
3
7
6
Late-stage studies
Recruiting
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Most influential
Major themes1
- Meniere Disease1
Leading journals1
- Genes and immunity1
Leading researchers8
- Domínguez-Durán E1
- Escalera-Balsera A1
- Flook M1
- Frejo L1
- G Ranea JA1
- Gallego-Martinez A1
- Gonzalez-Aguado R1
- Lopez-Escamez JA1
Affiliations (unnormalised)6
- Hospital Clínic1
- Hospital Universitario Marques de Valdecilla1
- Hospital Universitario San Cecilio1
- Hospital Universitario Virgen Macarena1
- Institute of Biomedical Research in Malaga (IBIMA-Plataforma BIONAND)1
- Instituto de Investigación Biosanitaria1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
A disease of the inner ear (LABYRINTH) that is characterized by fluctuating SENSORINEURAL HEARING LOSS; TINNITUS; episodic VERTIGO; and aural fullness. It is the most common form of endolymphatic hydrops.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.