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Disease

Mitral Valve Insufficiency

Late-stage therapeutic developmentEmerging researchSteady momentum
MeSHMitral Valve Insufficiency
4
Publications
13
Clinical trials
2
Related conditions
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q3 2027.
Upcoming Milestones
Clinical Milestones2View
Results posted 1
Results expected 1
Activity timeline2

Clinical trials

9 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
13
All trials
2
Active
5
Late-stage
6
Completed
Late-stage studies

Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Assess the Efficacy of Ertugliflozin on Reduction of Mitral Regurgitation in Patients With Functional Mitral Regurgitation Secondary to Left Ventricular Dysfunction

Phase 3 · Completed · Asan Medical Center

Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults: a Randomized Clinical Trial

Phase 3 · Completed · Astana Medical University

Multicenter, Randomized, Double-blind, Active-controlled Study to Assess the Efficacy of LCZ696 Compared to Valsartan on Reduction of Mitral Regurgitation in Patients With Left Ventricular Dysfunction and Secondary Functional Mitral Regurgitation of Stage B and C

Phase 4 · Completed · Asan Medical Center

High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Randomized Controlled Trial Comparing MitraClip® to Surgical Therapy

Phase 4 · Terminated · University of Zurich

Surgery Versus Medical Treatment Alone for Patients With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure: SMMART-HF

Phase 3 · Terminated · Duke University
Recently completed

Randomised Investigation of the MitraClip Device in Heart Failure: 2nd Trial in Patients With Clinically Significant Functional Mitral Regurgitation

N/A · Completed · University Medical Center Goettingen

Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Assess the Efficacy of Ertugliflozin on Reduction of Mitral Regurgitation in Patients With Functional Mitral Regurgitation Secondary to Left Ventricular Dysfunction

Phase 3 · Completed · Asan Medical Center

Effect of Anesthetics on Troponin I and С-reactive Protein in Mitral, Tricuspid and Aortic Valve Replacement/Plastic in Adult: a Randomized Clinical Study

Phase 1 · Completed · Astana Medical University

Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults: a Randomized Clinical Trial

Phase 3 · Completed · Astana Medical University

Multicenter, Randomized, Double-blind, Active-controlled Study to Assess the Efficacy of LCZ696 Compared to Valsartan on Reduction of Mitral Regurgitation in Patients With Left Ventricular Dysfunction and Secondary Functional Mitral Regurgitation of Stage B and C

Phase 4 · Completed · Asan Medical Center

A Study of the Evalve Cardiovascular Valve Repair System Endovascular Valve Edge-to-Edge REpair STudy (EVEREST I).

Phase 1/2 · Completed · Abbott Medical Devices

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20222024
Major themes6
  • Heart Valve Diseases4
  • Mitral Valve Insufficiency4
  • Tricuspid Valve Insufficiency2
  • Amyloidosis1
  • Aortic Valve Stenosis1
  • Heart Valve Prosthesis Implantation1
Leading journals4
  • European heart journal1
  • European heart journal. Cardiovascular Imaging1
  • Heart failure reviews1
  • The Lancet. Digital health1
Leading researchers8
  • Delgado V2
  • Vahanian A2
  • Aimo A1
  • Badano L1
  • Baldus S1
  • Barison A1
  • Bauersachs J1
  • Beyersdorf F1
Affiliations (unnormalised)6
  • Anthea Hospital1
  • BHF Centre for Cardiovascular Science1
  • Center for Diagnosis and Treatment of Cardiomyopathies1
  • Emeritus Professor of Clinical Cardiology1
  • Graduate School of Medicine1
  • ICMI (In Vivo Cellular and Molecular Imaging) Laboratory1

Related conditions

2 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Heart Valve Diseases4Tricuspid Valve Insufficiency2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.

Identifiers
MeSHMitral Valve Insufficiency
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.