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Disease
Tricuspid Valve Insufficiency
Active therapeutic pipelineEmerging research
3
Publications
3
Clinical trials
2
Related conditions
2024
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Tricuspid valve disease and cardiac implantable electronic devices.
Research2024-02-01European heart journal
Valvular heart disease in patients with cardiac amyloidosis.
Research2023-09-22Heart failure reviews
Research2022-04-01European heart journal. Cardiovascular Imaging
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 2 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
- Q4 2027A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Tricuspid Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System and Optimal Medical Therapy (OMT) Compared to OMT Alone in Patients With Tricuspid Regurgitation
- Q3 2028A Prospective, Multicenter, Randomized Controlled Clinical Trial Protocol Evaluating the Safety and Efficacy of the TruGamma Transcatheter Tricuspid Valve System in Patients With Severe Tricuspid Regurgitation
Major developments
Upcoming trial readoutImportant
Results expected Q3 20282026-07-08
Upcoming trial readoutImportant
Results expected Q4 20272026-07-06
Clinical MilestonesViewHide
Results expected
- 2026-07-08A Prospective, Multicenter, Randomized Controlled Clinical Trial Protocol Evaluating the Safety and Efficacy of the TruGamma Transcatheter Tricuspid Valve System in Patients With Severe Tricuspid RegurgitationResults expected Q3 2028
- 2026-07-06A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Tricuspid Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System and Optimal Medical Therapy (OMT) Compared to OMT Alone in Patients With Tricuspid RegurgitationResults expected Q4 2027
Recently completed
Activity timeline3
- 2026-07-08ClinicalA Prospective, Multicenter, Randomized Controlled Clinical Trial Protocol Evaluating the Safety and Efficacy of the TruGamma Transcatheter Tricuspid Valve System in Patients With Severe Tricuspid RegurgitationResults expected Q3 2028
- 2026-07-06ClinicalA Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Tricuspid Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System and Optimal Medical Therapy (OMT) Compared to OMT Alone in Patients With Tricuspid RegurgitationResults expected Q4 2027
- 2025-12-05ClinicalEdwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy Using a Novel DevicePrimary completion
Clinical trials
The current development programme across all trial phases.
Clinical programme
3
3
0
0
Recruiting
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Publications over time
20222024
Most influential
Major themes8
- Tricuspid Valve Insufficiency3
- Heart Valve Diseases2
- Mitral Valve Insufficiency2
- Amyloidosis1
- Aortic Valve Stenosis1
- Defibrillators, Implantable1
- Pacemaker, Artificial1
- Rheumatic Heart Disease1
Leading journals3
- European heart journal1
- European heart journal. Cardiovascular Imaging1
- Heart failure reviews1
Leading researchers8
- Badano L2
- Aimo A1
- Andreas M1
- Barison A1
- Barreiro M1
- Burri H1
- Camerini L1
- Castiglione V1
Affiliations (unnormalised)6
- University of Rennes2
- Allina Health Minneapolis Heart Institute at Abbott Northwestern Hospital1
- Anthea Hospital1
- Bern University Hospital1
- BHF Centre for Cardiovascular Science1
- Cardiovascular Center1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Backflow of blood from the RIGHT VENTRICLE into the RIGHT ATRIUM due to imperfect closure of the TRICUSPID VALVE.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.