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Disease

Multiple cutaneous and mucosal venous malformations

Late-stage therapeutic development
Also known as VMCM, cutaneous and mucosal venous malformation, VENOUS malformations, multiple cutaneous and mucosal, Vmcm1+1 more

VMCM, cutaneous and mucosal venous malformation, VENOUS malformations, multiple cutaneous and mucosal, Vmcm1, mucocutaneous venous malformations.

18
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones5View
Results expected 3
Recently completed 2
Activity timeline5

Clinical trials

14 sponsors · 2 new · 1 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
12
Late-stage
6
Completed
Late-stage studies

Breast Cancer Liver Metastases-2 - A Multicentre Randomized Clinical Trial Investigating Local Treatment for Breast Cancer Liver Metastases

Phase 3 · Recruiting · Umeå University

Systematic Management Approach for Children and Adolescents With Orbital Lymphatic Malformation

Phase 3 · Recruiting · Ain Shams University

Randomised Controlled Trial of Foam Sclerotherapy Versus Ambulatory Phlebectomy for the Treatment of Varicose Vein Tributaries

Phase 4 · Recruiting · Imperial College London

Evaluation of Liquorice Nanogel Versus Diode Laser as an Adjunctive Treatment for Patients With Periodontitis Stage Ⅲ.

Phase 3 · Completed · Al-Azhar University

Enhancing Skin Rejuvenation A Single-Blind, Randomized Control Study on the Combined Efficacy of Aerolase 1064 nm YAG Laser and Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells

Phase 3 · Completed · Laser Beamer Skincare

The Desensitising Effect of Nanosilver Fluoride Compared to Low-Level Laser Therapy in Molar-Incisor Hypomineralisation: A Randomised Controlled Clinical Trial

Phase 2/3 · Completed · Alexandria University
Recruiting

Breast Cancer Liver Metastases-2 - A Multicentre Randomized Clinical Trial Investigating Local Treatment for Breast Cancer Liver Metastases

Phase 3 · Recruiting · Umeå University

Systematic Management Approach for Children and Adolescents With Orbital Lymphatic Malformation

Phase 3 · Recruiting · Ain Shams University

Randomised Controlled Trial of Foam Sclerotherapy Versus Ambulatory Phlebectomy for the Treatment of Varicose Vein Tributaries

Phase 4 · Recruiting · Imperial College London

Efficacy of High-Level Laser Therapy in Managing Oral Mucositis Among Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Randomized Controlled Clinical Trial

N/A · Recruiting · Ain Shams University

Comparative Study Between Nd:YAG Laser Combined With Injection Sclerotherapy Versus Diode Laser in the Treatment of Reticular Veins and Telangiectasias Using CLaCS Technique

N/A · Recruiting · Ain Shams University
Recently completed

Evaluation of Liquorice Nanogel Versus Diode Laser as an Adjunctive Treatment for Patients With Periodontitis Stage Ⅲ.

Phase 3 · Completed · Al-Azhar University

Enhancing Skin Rejuvenation A Single-Blind, Randomized Control Study on the Combined Efficacy of Aerolase 1064 nm YAG Laser and Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells

Phase 3 · Completed · Laser Beamer Skincare

The Desensitising Effect of Nanosilver Fluoride Compared to Low-Level Laser Therapy in Molar-Incisor Hypomineralisation: A Randomised Controlled Clinical Trial

Phase 2/3 · Completed · Alexandria University

Evaluation of Low-Level Laser Therapy as Adjunctive to the Injectable Platelet-Rich Fibrin in the Management of Patients With Thin Gingival Phenotype.

Phase 3 · Completed · Faculty of Dental Medicine for Girls

A Phase IV Randomised Clinical Trial of Laser Therapy for Peripheral Retinal Ischaemia Combined With Intravitreal Aflibercept (Eylea®) Versus Intravitreal Aflibercept Monotherapy for Diabetic Macular Oedema

Phase 4 · Completed · University of Sydney

ANCHOR Study: Anal Cancer/HSIL Outcomes Research Study

Phase 3 · Completed · AIDS Malignancy Consortium

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

TEK0.81

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Angiopoietin-1 receptorvia TEK0.81

Reference

Authoritative identity, definition & identifiers.

Synonyms

VMCM, cutaneous and mucosal venous malformation, VENOUS malformations, multiple cutaneous and mucosal, Vmcm1, mucocutaneous venous malformations

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.