TEK

Gene

TEK receptor tyrosine kinase

HGNCHGNC:11724 EnsemblENSG00000120156 NCBI Gene7010

Locus: gene with protein productLocation: 9p21.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Angiopoietin-1 receptorQ02763

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asVMCM · TIE2 · TIE-2 · VMCM1 · CD202b

View full nomenclature history (8)

Previous symbolsVMCM

Alias symbolsTIE2, TIE-2, VMCM1, CD202b

Previous namesvenous malformations, multiple cutaneous and mucosal, TEK tyrosine kinase, endothelial

Alias namesangiopoietin-1 receptor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple cutaneous and mucosal venous malformations

Mucocutaneous venous malformations

Congenital glaucoma

Colorectal Neoplasms

Medullary thyroid gland carcinoma

Vascular Malformations

Neoplasms

Metastatic colorectal cancer

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesFibronectin type III domain containingImmunoglobulin like domain containingTyrosine kinase with immunoglobulin like and EGF like domains family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.