multiple endocrine neoplasia type 2A
Also known as MEA type 2a, MEA type II, MEN2A, RET-related multiple endocrine neoplasia type 2A+19 more
MEA type 2a, MEA type II, MEN2A, RET-related multiple endocrine neoplasia type 2A, Sipple syndrome, men 2A, men type 2a, men type II, multiple endocrine adenomatosis type 2A, multiple endocrine adenomatosis type 2a, multiple endocrine adenomatosis type II, multiple endocrine adenomatosis, type II, multiple endocrine neoplasia II, multiple endocrine neoplasia IIA, multiple endocrine neoplasia type II, multiple endocrine neoplasia, type II, ptc syndrome, men-2A syndrome, multiple endocrine neoplasia, type 2A, multiple endocrine neoplasia, type IIA, pheochromocytoma and amyloid producing medullary thyroid carcinoma, pheochromocytoma and amyloid-producing medullary thyroid carcinoma, thyroid carcinoma, familial medullary.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
MEA type 2a, MEA type II, MEN2A, RET-related multiple endocrine neoplasia type 2A, Sipple syndrome, men 2A, men type 2a, men type II, multiple endocrine adenomatosis type 2A, multiple endocrine adenomatosis type 2a, multiple endocrine adenomatosis type II, multiple endocrine adenomatosis, type II, multiple endocrine neoplasia II, multiple endocrine neoplasia IIA, multiple endocrine neoplasia type II, multiple endocrine neoplasia, type II, ptc syndrome, men-2A syndrome, multiple endocrine neoplasia, type 2A, multiple endocrine neoplasia, type IIA, pheochromocytoma and amyloid producing medullary thyroid carcinoma, pheochromocytoma and amyloid-producing medullary thyroid carcinoma, thyroid carcinoma, familial medullary
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Related entities are derived from literature co-mention (studied together) — associative, not causal.