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RET

Gene

ret proto-oncogene

HGNCHGNC:9967EnsemblENSG00000165731NCBI Gene5979
Locus: gene with protein productLocation: 10q11.21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proto-oncogene tyrosine-protein kinase receptor RetP07949

Protein · therapeutic target

Clinically validated target · 12 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHSCR1 · MEN2A · MTC1 · MEN2B · PTC · CDHF12 · RET51 · CDHR16
View full nomenclature history (13)
Previous symbolsHSCR1, MEN2A, MTC1, MEN2B
Alias symbolsPTC, CDHF12, RET51, CDHR16
Previous namesmultiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease 1
Alias namescadherin-related family member 16, RET receptor tyrosine kinase, rearranged during transfection

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Medullary thyroid gland carcinoma
multiple endocrine neoplasia type 2A
multiple endocrine neoplasia type 2B
Hirschsprung disease
Pheochromocytoma
Multiple endocrine neoplasia type 2
Familial medullary thyroid carcinoma
Carcinoma, Non-Small-Cell Lung
Carcinoma, Hepatocellular
Multiple endocrine neoplasia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cadherin relatedRet proto-oncogene family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-02-19.
Open TargetsGene–disease associations from the Open Targets Platform.