multiple endocrine neoplasia type 2B
Also known as MEN2B, RET-related multiple endocrine neoplasia type 2B, Wagenmann-Froboese syndrome, men 2B+18 more
MEN2B, RET-related multiple endocrine neoplasia type 2B, Wagenmann-Froboese syndrome, men 2B, men IIB, men type 2B, men type IIB, mucosal neuroma syndrome, multiple endocrine adenomatosis type IIB, multiple endocrine neoplasia IIB, multiple endocrine neoplasia type 3, multiple endocrine neoplasia type IIB, multiple endocrine neoplasia type III, multiple endocrine neoplasia, type 3, multiple endocrine neoplasia, type III, Neuromata, mucosal, with endocrine tumors, Neuromata, mucosal, with endocrine tumours, mucosal Neuroma syndrome, multiple endocrine neoplasia, type 2B, multiple endocrine neoplasia, type 3 (formerly), multiple endocrine neoplasia, type IIB, multiple endocrine neoplasia, type III, formerly.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
MEN2B, RET-related multiple endocrine neoplasia type 2B, Wagenmann-Froboese syndrome, men 2B, men IIB, men type 2B, men type IIB, mucosal neuroma syndrome, multiple endocrine adenomatosis type IIB, multiple endocrine neoplasia IIB, multiple endocrine neoplasia type 3, multiple endocrine neoplasia type IIB, multiple endocrine neoplasia type III, multiple endocrine neoplasia, type 3, multiple endocrine neoplasia, type III, Neuromata, mucosal, with endocrine tumors, Neuromata, mucosal, with endocrine tumours, mucosal Neuroma syndrome, multiple endocrine neoplasia, type 2B, multiple endocrine neoplasia, type 3 (formerly), multiple endocrine neoplasia, type IIB, multiple endocrine neoplasia, type III, formerly
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Related entities are derived from literature co-mention (studied together) — associative, not causal.