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Disease

Osteoarthritis, Knee

Late-stage therapeutic developmentEmerging researchSteady momentum
MeSHOsteoarthritis, Knee
4
Publications
22
Clinical trials
12
Associated genes
5
Related proteins
2024
Latest publication
Current focus
Integrin alpha-2 biologyTenascin biologyTherapeutic developmentGenetics & risk factorsInflammation & immunity
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 5 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones8View
Results posted 2
Results expected 5
Recently completed 1
Activity timeline8

Clinical trials

18 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
22
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

The Effect of ColcHicine on the Incidence of Knee or Hip Replacements: a Randomized, Double-blind, Multicentre Study in Symptomatic Knee or Hip Osteoarthritis

Phase 3 · Recruiting · Sint Maartenskliniek

Intra-Articular Autologous Bone Marrow Aspirate vs Placebo Injection and Lipoaspirate Micronized With Leukocyte-Poor Platelet Rich Plasma vs Placebo Injection Evaluations for Treatment of Knee OsteoArthritis: The ABLE OA Double-Blinded Randomized Clinical Trial

Phase 2/3 · Recruiting · University Health Network, Toronto

N of 1 Pilot Study of Nonsteroidal Anti-inflammatory Drugs in People With Painful Knee Osteoarthritis

Phase 4 · Active, not recruiting · Northwestern University

A 48-Weeks, Phase 2b/3a, Double-Blind, Randomized, Placebo Controlled, Multi-center, Superiority Study to Evaluate the Efficacy and Safety of JointStem, Autologous Adipose Tissue Derived Mesenchymal Stem Cells in Patients Diagnosed as Knee Osteoarthritis

Phase 2/3 · Active, not recruiting · Nature Cell Co. Ltd.

A Phase 3, Randomised, Double-Blind, Placebo-Controlled Multi-Centre Study to Evaluate the Treatment Effect of Pentosan Polysulfate Sodium Compared to Placebo in Participants With Knee Osteoarthritis Pain

Phase 3 · Active, not recruiting · Paradigm Biopharmaceuticals Ltd.

RCT to Evaluate the Effects of Zilretta (Triamcinolone Acetonide- Extended Release) and Kenalog (Triamcinolone Acetonide- Immediate Release) on Blood Glucose in Subjects With Osteoarthritis of the Knee and Type 2 Diabetes Mellitus

Phase 4 · Recruiting · University of Kansas Medical Center
Recruiting

The Effect of ColcHicine on the Incidence of Knee or Hip Replacements: a Randomized, Double-blind, Multicentre Study in Symptomatic Knee or Hip Osteoarthritis

Phase 3 · Recruiting · Sint Maartenskliniek

Intra-Articular Autologous Bone Marrow Aspirate vs Placebo Injection and Lipoaspirate Micronized With Leukocyte-Poor Platelet Rich Plasma vs Placebo Injection Evaluations for Treatment of Knee OsteoArthritis: The ABLE OA Double-Blinded Randomized Clinical Trial

Phase 2/3 · Recruiting · University Health Network, Toronto

RCT to Evaluate the Effects of Zilretta (Triamcinolone Acetonide- Extended Release) and Kenalog (Triamcinolone Acetonide- Immediate Release) on Blood Glucose in Subjects With Osteoarthritis of the Knee and Type 2 Diabetes Mellitus

Phase 4 · Recruiting · University of Kansas Medical Center
Recently completed

Route of Dexamethasone Administration in iPACK and ACB for Total Knee Replacement: A Randomized Trial

Phase 4 · Completed · Poznan University of Medical Sciences

The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis

Phase 3 · Completed · Stanford University

Effect of Knee Pain on Walking Biomechanics

Phase 4 · Completed · The Cleveland Clinic

Evaluation of the Effect of Triamcinolone at Different Doses on Local Infiltration Anesthesia During Total Knee Arthroplasty

Phase 4 · Completed · Peking University Third Hospital

Whole-body Electromyostimulation for the Treatment of Knee Osteoarthritis (EMSOAT) in Overweight People - a Randomized Controlled Trial

Phase 3 · Completed · University of Erlangen-Nürnberg Medical School

Ultrasound-guided Injection of Glucocorticoid Into Infrapatellar Fat Pad Versus Placebo Injection in Knee Osteoarthritis: a 12-week Double-blinded Controlled Trial

Phase 4 · Completed · Zhujiang Hospital

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20022024
Major themes7
  • Bone Marrow Transplantation1
  • Cytokines1
  • Genome-Wide Association Study1
  • Mendelian Randomization Analysis1
  • Osteoarthritis, Knee1
  • Polymorphism, Single Nucleotide1
  • Robotic Surgical Procedures1
Leading journals3
  • Osteoarthritis and cartilage2
  • Frontiers in immunology1
  • The Journal of arthroplasty1
Leading researchers8
  • Abramson S1
  • Altman RD1
  • Arden N1
  • Banger MS1
  • Bierma-Zeinstra S1
  • Blyth MJG1
  • Brandt KD1
  • Croft P1
Affiliations (unnormalised)5
  • Glasgow Royal Infirmary1
  • Nursing School1
  • Sinshu University School of Medicine1
  • University of Edinburgh1
  • University of Strathclyde1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

NGF0.55ACAN0.52COLGALT20.51COL27A10.51TACC30.51WSCD20.50SOX50.50FES0.49USP80.48TEAD10.47ALDH1A20.47FGF180.47

Disease biology

5 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Beta-nerve growth factorvia NGF0.55Tenascinvia TNC0.39Integrin alpha-2via ITGA20.25Tumor necrosis factor receptor superfamily member 9via TNFRSF90.15Somatostatinvia SST0.11

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

Identifiers
MeSHOsteoarthritis, Knee
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.