Out-of-Hospital Cardiac Arrest
Recent clinical, regulatory, research and industry developments relating to this disease.
Bag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study.
Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest.
Targeted temperature management at 33°C versus 36°C after cardiac arrest.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q4 2027.
- 1 industry development reported.
Clinical MilestonesViewHide
- 2026-04-21Resuscitation Enhancement to Avoid Rearrest Through Evidence-based Strategies in Prehospital Post-resuscitation CareResults expected Q4 2027
Industry & MarketViewHide
- 2026-07-21Spatial inequalities in out-of-hospital cardiac arrest in Lombardy, Italy are associated with ageing, population density and low incomeIndustry · Nature — Environmental Sciences
- 2026-07-31ClinicalA Randomized Clinical Trial of Patient Outcomes Following Out-of-Hospital Cardiac Arrest Receiving Epinephrine Versus In-together Vasopressin, Epinephrine, and Steroid. (OHCA REVIVES Trial)Primary completion
- 2026-07-21IndustrySpatial inequalities in out-of-hospital cardiac arrest in Lombardy, Italy are associated with ageing, population density and low incomeIndustry · Nature — Environmental Sciences
- 2026-04-21ClinicalResuscitation Enhancement to Avoid Rearrest Through Evidence-based Strategies in Prehospital Post-resuscitation CareResults expected Q4 2027
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes7
- Out-of-Hospital Cardiac Arrest5
- Hypothermia, Induced3
- Cardiopulmonary Resuscitation2
- Hypercapnia1
- Patient Transfer1
- Photoplethysmography1
- Wearable Electronic Devices1
Leading journals6
- Circulation2
- The New England journal of medicine2
- European heart journal1
- Lancet (London, England)1
- Resuscitation1
- Scientific reports1
Leading researchers8
- Brunetti I2
- Callaway C2
- Christenson J2
- Cronberg T2
- Erlinge D2
- Friberg H2
- Hovdenes J2
- Lilja G2
Affiliations (unnormalised)6
- University of British Columbia2
- Austin Hospital1
- Barts Heart Centre1
- Brompton and Harefield NHS Foundation Trust1
- Centre for Advancing Health Outcomes1
- Centre for Aging SMART1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Out-of-hospital cardiac arrest is a cardiac arrest that occurs when a person does not have immediate access to medical personnel or equipment. It is a medical emergency defined by the setting in which the arrest occurs rather than by a specific underlying disease process.
The supplied grounding does not describe the biological mechanism of out-of-hospital cardiac arrest itself. The only mechanism-related topic co-studied with it is body temperature, reflecting the literature on post-arrest temperature management rather than the arrest mechanism.
The literature grounding emphasizes post-cardiac arrest temperature management for comatose adult survivors after return of spontaneous circulation. This includes targeted temperature management and strict normothermia as treatment strategies, with earlier practice centered on mild therapeutic hypothermia and later recommendations shifting after trials showed no advantage of lower temperature targets over higher targets or strict normothermia.
AI-generated summary grounded in MeSH and 1 peer-reviewed source. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.