Primary Ovarian Insufficiency
Recent clinical, regulatory, research and industry developments relating to this disease.
Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial with recent milestones.
Clinical MilestonesViewHide
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes4
- Endocrinology2
- Hypogonadism1
- Menopause1
- Perimenopause1
Leading journals3
- Clinical endocrinology1
- European journal of endocrinology1
- Human reproduction update1
Leading researchers8
- Anderson RA2
- Jayasena CN2
- Barber K1
- Comninos AN1
- Conway GS1
- Crown A1
- Davies MC1
- De Felici M1
Affiliations (unnormalised)6
- Imperial College London2
- MRC Centre for Reproductive Health2
- Department of Clinical Epidemiology1
- Erasmus Medical Center1
- Hammersmith Hospital1
- Imperial College Healthcare NHS Trust1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.