REM Sleep Behavior Disorder
Recent clinical, regulatory, research and industry developments relating to this disease.
Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 5 clinical trials with recent milestones.
Clinical MilestonesViewHide
- 2026-07-01The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's DiseasePrimary completion
- 2026-06-30The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease: A Follow up StudyPrimary completion
- 2026-03-10The Effect of alpha1- Adrenergic Receptor Antagonist Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease: A Follow up StudyPrimary completion
- 2025-12-10The Effect of a1- Adrenergic Receptor Antagonist Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's DiseasePrimary completion
- 2026-12-31Efficacy and Safety of Rasagiline in Prodromal Parkinson's DiseaseWithdrawn
- 2026-12-31ClinicalEfficacy and Safety of Rasagiline in Prodromal Parkinson's DiseaseWithdrawn
- 2026-07-01ClinicalThe Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's DiseasePrimary completion
- 2026-06-30ClinicalThe Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease: A Follow up StudyPrimary completion
- 2026-03-10ClinicalThe Effect of alpha1- Adrenergic Receptor Antagonist Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease: A Follow up StudyPrimary completion
- 2025-12-10ClinicalThe Effect of a1- Adrenergic Receptor Antagonist Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's DiseasePrimary completion
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes2
- Parkinson Disease1
- REM Sleep Behavior Disorder1
Leading journals1
- The Lancet. Neurology1
Leading researchers8
- Albin RL1
- Bedard MA1
- Bohnen NI1
- Borghammer P1
- Moehle MS1
- Moro E1
- Weil RS1
- Yarnall AJ1
Affiliations (unnormalised)6
- Aarhus University Hospital1
- Canada; McConnell Brain Imaging Centre1
- Dementia Research Centre1
- France; Grenoble Alpes University1
- Translational and Clinical Research Institute1
- University of Florida1
Reference
Authoritative identity, definition & identifiers.
A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.