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SNCA

Gene

synuclein alpha

HGNCHGNC:11138EnsemblENSG00000145335NCBI Gene6622
Locus: gene with protein productLocation: 4q22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Alpha-synucleinP37840

Protein · therapeutic target

Clinical-stage target · 2 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPARK1 · PARK4 · NACP · PD1
View full nomenclature history (9)
Previous symbolsPARK1, PARK4
Alias symbolsNACP, PD1
Previous namesParkinson disease (autosomal dominant, Lewy body) 4, synuclein, alpha (non A4 component of amyloid precursor)
Alias namesnon A4 component of amyloid precursor, alpha-synuclein, α-synuclein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lewy Body Disease
Parkinson's Disease
Immunoglobulin Light-chain Amyloidosis
Sleep Initiation and Maintenance Disorders
REM Sleep Behavior Disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Synuclein family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.