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Disease
Smoking cessation
Late-stage therapeutic development
24
Clinical trials
12
Associated genes
3
Related proteins
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Clinical trial2026-07-08Status changed to Active, not recruiting · ClinicalTrials.gov
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 5 clinical trials expected to report results, the earliest in Q3 2027.
- 1 industry development reported.
Upcoming Milestones
- Q3 2027Evaluating Smoking Cessation Interventions for PWH in South Africa: Efficacy, Implementation, and Cost-effectiveness
- Q3 2027Smoking Cessation Treatment for Head & Neck Cancer Patients: Acceptance and Commitment Therapy
- Q2 2028Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care
- Q1 2029A Randomized, Placebo Controlled, Double Blind, Double Dummy, Multicenter Trial Comparing Electronic Cigarettes With Nicotine to Varenicline and to Electronic Cigarettes Without Nicotine.
- Q1 2030Comparing Three Multicomponent Interventions to Help Adults Quit Smoking
Major developments
Major trial resultsHigh impact
Results posted2026-06-26
Major trial resultsHigh impact
Results posted2026-05-22
Clinical MilestonesView all 13Hide
Results posted
- 2026-06-26BREATHE 2 Cluster-randomized Trial of Health System Changes to Increase Reach of Smoking Cessation TreatmentsResults posted
- 2026-05-22Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary CareResults posted
Results expected
- 2026-07-01Comparing Three Multicomponent Interventions to Help Adults Quit SmokingResults expected Q1 2030
- 2026-06-15Smoking Cessation Treatment for Head & Neck Cancer Patients: Acceptance and Commitment TherapyResults expected Q3 2027
- 2026-06-09Evaluating Smoking Cessation Interventions for PWH in South Africa: Efficacy, Implementation, and Cost-effectivenessResults expected Q3 2027
- 2026-04-13Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical CareResults expected Q2 2028
- 2025-12-29A Randomized, Placebo Controlled, Double Blind, Double Dummy, Multicenter Trial Comparing Electronic Cigarettes With Nicotine to Varenicline and to Electronic Cigarettes Without Nicotine.Results expected Q1 2029
Recently completed
- 2026-04-30Coordinating Smoking Cessation Treatment With Menstrual Cycle Phase to Improve Quit Outcomes: A Randomized Controlled TrialPrimary completion
- 2025-12-12Cytisine: Testing Its Potential as a Therapeutic Strategy for Smoking Cessation Among People With Concurrent Alcohol Use DisorderCompleted
- 2025-12-09Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine RespondersCompleted
- 2025-10-13A Randomized Controlled Trial to Determine the Effects of Combination Zonisamide and Bupropion on Switching to an Electronic CigaretteCompleted
- 2025-10-06A Multicenter, Open-Label Study Assessing Long-Term Exposure With Cytisinicline 3 mg TIDCompleted
+5 more in the activity timeline below
Industry & MarketViewHide
- 2026-08-18Virtual smoking cessation program benefits patients with cancerIndustry · Healio Neurology
Activity timeline14
- 2026-08-18IndustryVirtual smoking cessation program benefits patients with cancerIndustry · Healio Neurology
- 2026-07-01ClinicalComparing Three Multicomponent Interventions to Help Adults Quit SmokingResults expected Q1 2030
- 2026-06-26ClinicalBREATHE 2 Cluster-randomized Trial of Health System Changes to Increase Reach of Smoking Cessation TreatmentsResults posted
- 2026-06-15ClinicalSmoking Cessation Treatment for Head & Neck Cancer Patients: Acceptance and Commitment TherapyResults expected Q3 2027
- 2026-06-09ClinicalEvaluating Smoking Cessation Interventions for PWH in South Africa: Efficacy, Implementation, and Cost-effectivenessResults expected Q3 2027
- 2026-05-22ClinicalEffectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary CareResults posted
- 2026-04-30ClinicalCoordinating Smoking Cessation Treatment With Menstrual Cycle Phase to Improve Quit Outcomes: A Randomized Controlled TrialPrimary completion
- 2026-04-13ClinicalUsing Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical CareResults expected Q2 2028
- 2026-01-01ClinicalA Randomized Open-label, Superiority, Multicenter, Two-arm Intervention Study of the Effect of "High-intensity" vs. 'Low-intensity' Smoking Cessation Intervention in Active Smokers With COPDWithdrawn
- 2025-12-29ClinicalA Randomized, Placebo Controlled, Double Blind, Double Dummy, Multicenter Trial Comparing Electronic Cigarettes With Nicotine to Varenicline and to Electronic Cigarettes Without Nicotine.Results expected Q1 2029
Therapeutic landscape
Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.
Approved & established therapies
Vareniclineapproved
Approval — Champix is indicated for smoking cessation in adults. (2006)
Clinical trials
The current development programme across all trial phases.
Clinical programme
24
6
17
6
Late-stage studies
Recruiting
Recently completed
Regulatory timeline
Drug regulatory events matched to this condition by indication — EMA.
First approvals
European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Related entities are derived from literature co-mention (studied together) — associative, not causal.