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Disease

Sprain

Late-stage therapeutic development
16
Clinical trials
10
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones5View
Results expected 3
Recently completed 2
Activity timeline5

Clinical trials

15 sponsors · 3 new · 1 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme
16
All trials
4
Active
13
Late-stage
6
Completed
Late-stage studies

Botulinum Toxin Injection in the Management of Thumb Carpometacarpal Arthritis: a Randomized Controlled Trial

Phase 3 · Recruiting · Rhode Island Hospital

Topical Diclofenac vs. Oral Ibuprofen for Musculoskeletal Pain in Children: A Multi-centre, Randomized Pilot Feasibility Trial

Phase 3 · Recruiting · University of Calgary

Efficacy & Safety of Piroxicam Plus Counterirritant Gel Compared With Other Topical Non-Steroid Anti-Inflammatory Drugs in Managing Musculoskeletal Pain: A Randomized Clinical Study

Phase 3 · Completed · Taisho Pharmaceutical Indonesia

Effect of Allopurinol Administration on the Prevention of Muscle Mass Loss in Subject Immobilized.

Phase 3 · Completed · Instituto de Investigacion Sanitaria La Fe

Multi-centre, Double-blind, Randomised, Active- and Placebo-Controlled, Confirmatory Trial to Demonstrate Efficacy and Safety of Traumed® Gel in Patients Having Acute Ankle Sprain

Phase 3 · Completed · Biologische Heilmittel Heel GmbH

A Randomized, Double-blind, Placebo-controlled, Multi-dose, Pivotal Study to Determine the Efficacy and Safety of SST 0225, a Topical Ibuprofen Cream, in the Treatment of Pain Associated With Acute Ankle Sprain.

Phase 3 · Completed · Strategic Science & Technologies, LLC
Recruiting

Botulinum Toxin Injection in the Management of Thumb Carpometacarpal Arthritis: a Randomized Controlled Trial

Phase 3 · Recruiting · Rhode Island Hospital

Clinical Outcomes Related to Treatment of Ankle Injury Using Semiconductor Embedded Therapeutic Socks: A Randomized, Prospective, Double Blinded Clinical Study

N/A · Recruiting · University of Colorado, Denver

Topical Diclofenac vs. Oral Ibuprofen for Musculoskeletal Pain in Children: A Multi-centre, Randomized Pilot Feasibility Trial

Phase 3 · Recruiting · University of Calgary

Comparison of Perineural Versus Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand and Forearm Surgery: A Randomized Double-Blind Placebo-Controlled Trial With Neurological Safety Evaluation and Neurofilament Light Chain Biomarker Assessment

N/A · Recruiting · Poznan University of Medical Sciences
Recently completed

Efficacy & Safety of Piroxicam Plus Counterirritant Gel Compared With Other Topical Non-Steroid Anti-Inflammatory Drugs in Managing Musculoskeletal Pain: A Randomized Clinical Study

Phase 3 · Completed · Taisho Pharmaceutical Indonesia

Multi-centre, Double-blind, Randomised, Active- and Placebo-Controlled, Confirmatory Trial to Demonstrate Efficacy and Safety of Traumed® Gel in Patients Having Acute Ankle Sprain

Phase 3 · Completed · Biologische Heilmittel Heel GmbH

Effect of Allopurinol Administration on the Prevention of Muscle Mass Loss in Subject Immobilized.

Phase 3 · Completed · Instituto de Investigacion Sanitaria La Fe

Comparison of Topical Dexketoprofen Versus Placebo in Patients Presented With Ankle Sprain to the Emergency Department: A Randomised Placebo Controlled Trial

Phase 4 · Completed · Akdeniz University

A Randomized, Double-blind, Placebo-controlled, Multi-dose, Pivotal Study to Determine the Efficacy and Safety of SST 0225, a Topical Ibuprofen Cream, in the Treatment of Pain Associated With Acute Ankle Sprain.

Phase 3 · Completed · Strategic Science & Technologies, LLC

A Randomized, Controlled, Multi-center Study on the Effectiveness of Traumeel S (Both Ointment and Gel) in Terms of Pain and Function Compared With a Topical NSAID in Athletes With Acute Ankle Sprain

Phase 3 · Completed · Biologische Heilmittel Heel GmbH

Associated genes

10 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

KCNK90.33GPR550.28RBFA0.22DSE0.22MCM60.22SEZ6L0.17UBE2Q20.14CEP150.09UBXN40.04ASPHD20.02

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Potassium channel subfamily K member 9via KCNK90.33
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.